{"id":"W4383186708","doi":"10.1002/anie.202306272","title":"A Fluorogenic DNAzyme for A Thermally Stable Protein Biomarker from <i>Fusobacterium nucleatum</i>, a Human Bacterial Pathogen","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Fusobacterium nucleatum; Pathogen; Human pathogen; Saliva; Biomarker; Computational biology; Biology; Microbiology; Chemistry; Biochemistry; Bacteria; Genetics; Porphyromonas gingivalis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003505569,0.0007255967,0.0002734134,0.0003205136,0.000173953,0.0002025724,0.0004230407,0.0008027771,0.001005785],"category_scores_gemma":[0.0004953091,0.0001931203,0.0002978503,0.0002539055,0.0003272778,0.0002083566,0.0001936505,0.0005477222,0.0006009369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004059865,"about_ca_system_score_gemma":0.0002394376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000427732,"about_ca_topic_score_gemma":0.000602919,"domain_scores_codex":[0.9996643,0.00006715486,0.00001937808,0.0001326819,0.00007860039,0.0000378288],"domain_scores_gemma":[0.9997275,0.00008661818,0.00008234127,0.00002180308,0.00004344811,0.00003820536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002124103,0.000007351696,0.00006573945,0.00003946724,0.000002248515,0.00002322579,0.000008846534,0.00004045334,0.9981678,0.00008090749,0.00003414267,0.001508548],"study_design_scores_gemma":[0.000004038634,0.00007539181,0.0003342476,0.00000444789,0.00000487564,0.0001304133,0.000003918935,0.0002272345,0.9977589,0.00001310043,0.001440395,0.000003016207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7031116,0.006822506,0.2794682,0.0006531062,0.000296712,0.000469069,0.0008544651,0.0008158053,0.007508358],"genre_scores_gemma":[0.8289576,0.001895141,0.1591366,0.0003865799,0.00003391374,0.00035369,0.001294216,0.00007103728,0.007871251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005785,"threshold_uncertainty_score":0.003364742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708676706962795,"score_gpt":0.2772551501516638,"score_spread":0.2601683830820358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}