{"id":"W4383186708","doi":"10.1002/anie.202306272","title":"A Fluorogenic DNAzyme for A Thermally Stable Protein Biomarker from <i>Fusobacterium nucleatum</i>, a Human Bacterial Pathogen","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Fusobacterium nucleatum; Pathogen; Human pathogen; Saliva; Biomarker; Computational biology; Biology; Microbiology; Chemistry; Biochemistry; Bacteria; Genetics; Porphyromonas gingivalis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701383,0.0001893139,0.0001493835,0.00007855966,0.000113497,0.00007143365,0.0002167531,0.0001863059,0.00006947412],"category_scores_gemma":[0.00008591209,0.0001808644,0.000194147,0.0001123626,0.00005868043,0.0000206849,0.0001086977,0.00006236881,0.00001282612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005541655,"about_ca_system_score_gemma":0.00004030395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003363251,"about_ca_topic_score_gemma":0.00003304725,"domain_scores_codex":[0.9988523,0.00002397431,0.0002527684,0.0004388019,0.0001929778,0.0002391427],"domain_scores_gemma":[0.9993235,0.00001446079,0.0001462677,0.0002331137,0.0002231871,0.00005946023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002016643,0.00005499924,0.00004331235,0.000008599423,0.0001337618,0.000004179392,0.00001687411,3.871225e-7,0.9786609,0.00002104238,0.02018358,0.0006707077],"study_design_scores_gemma":[0.0005707793,0.00009392216,0.0004585223,0.000034445,0.00003417678,0.000003629,0.00002866529,0.00002989583,0.9271329,0.0006690163,0.0707294,0.0002146465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993426,0.00002742168,0.002277071,0.0004775859,0.0004596619,0.0003579726,0.002037471,0.0001678815,0.000768993],"genre_scores_gemma":[0.9721822,0.00004157809,0.001729031,0.0001968692,0.002092517,0.0001844447,0.02212826,0.00004177148,0.001403381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.051528,"threshold_uncertainty_score":0.7375437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708676706962795,"score_gpt":0.2772551501516638,"score_spread":0.2601683830820358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}