{"id":"W4383186826","doi":"10.55563/clinexprheumatol/8l7bbk","title":"Upadacitinib in patients with psoriatic arthritis and inadequate response to biologics: 3-year results from the open-label extension of the randomised controlled phase 3 SELECT-PsA 2 study","year":2023,"lang":"en","type":"article","venue":"Clinical and Experimental Rheumatology","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada); Probity Medical Research","funders":"Celgene; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Psoriatic arthritis; Internal medicine; Adverse effect; Population; Rheumatology; Psoriasis; Placebo; Arthritis; Surgery; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00705739,0.001009591,0.002681146,0.0003829731,0.0004369319,0.001148585,0.0005605259,0.001338503,0.002689296],"category_scores_gemma":[0.004407233,0.0004482421,0.002716869,0.000648558,0.00074653,0.001181804,0.0005402814,0.001743497,0.0004349252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007666594,"about_ca_system_score_gemma":0.001422177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000757608,"about_ca_topic_score_gemma":0.002062804,"domain_scores_codex":[0.9970849,0.001780169,0.0002361902,0.0002548317,0.0003484914,0.000295458],"domain_scores_gemma":[0.9958993,0.001057477,0.001529949,0.0004304182,0.0004168622,0.0006660894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9621177,0.005072912,0.006045034,0.0005824431,0.001853961,0.0000714968,0.0000931439,0.0003811797,0.001719178,0.00005584939,0.0008098416,0.0211972],"study_design_scores_gemma":[0.7808338,0.1696261,0.04306072,0.0001349336,0.002605729,0.0002305323,0.00009362688,0.0008903977,0.0007979819,0.0001665699,0.001511657,0.00004796311],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910551,0.004366093,0.0005521981,0.0002221337,0.0001199445,0.001523552,0.001274406,0.00004336301,0.0008431445],"genre_scores_gemma":[0.9936383,0.001465569,0.0006212786,0.0004464318,0.0001970913,0.001229801,0.00183274,0.00001080795,0.0005579264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00705739,"threshold_uncertainty_score":0.03732347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04481288090633665,"score_gpt":0.3672352585096877,"score_spread":0.322422377603351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}