{"id":"W4383187106","doi":"10.1111/febs.16873","title":"Role of developmental pathways in disease","year":2023,"lang":"en","type":"editorial","venue":"FEBS Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Epigenetics; Biology; Disease; Signal transduction; Neuroscience; Epigenesis; Human disease; Computational biology; Genetics; DNA methylation; Gene; Gene expression; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003870899,0.0001516369,0.0001832538,0.0001182776,0.00004296065,0.00002682793,0.0002055409,0.0003558435,0.00001770033],"category_scores_gemma":[0.0008099144,0.0001488563,0.0001131344,0.00008285048,0.00002692511,0.000002070615,0.0001050943,0.0003396281,0.00001231781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004263849,"about_ca_system_score_gemma":0.0007547956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009720608,"about_ca_topic_score_gemma":0.00004549456,"domain_scores_codex":[0.9987987,0.00006529551,0.0003748144,0.0002024584,0.0003565288,0.0002021918],"domain_scores_gemma":[0.9993261,0.00004552178,0.0002255842,0.0001268684,0.0001451229,0.0001307665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002930447,0.0001302494,0.003980611,0.00008553517,0.0001076791,0.00005990969,0.0001865048,0.0002133591,0.3639687,0.000006912219,0.623488,0.007479426],"study_design_scores_gemma":[0.0005428747,0.0001257724,0.003982904,0.0001215085,0.00002138345,0.000001216055,0.00006647693,0.00001255849,0.02110992,0.0008929212,0.9728815,0.0002409526],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.2894768,0.007380241,0.00008191375,0.00001763763,0.7020331,0.0001326233,0.000293527,0.000007347447,0.0005768524],"genre_scores_gemma":[0.1072331,0.008463597,0.0007437365,0.000007589122,0.8811395,0.00001657394,0.001549363,0.0001059544,0.0007406282],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.3493935,"threshold_uncertainty_score":0.6070185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101736973485786,"score_gpt":0.2523917446204153,"score_spread":0.2422180472718367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}