{"id":"W4383196636","doi":"10.21203/rs.3.rs-3067668/v1","title":"Generation of a C57Bl/6J mouse strain expressing the CD45.1 epitope to improve HSC engraftment and adoptive cell transfer experiments","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Université de Lyon; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale","keywords":"Epitope; Adoptive cell transfer; Strain (injury); Cell biology; Biology; Chemistry; Molecular biology; Virology; T cell; Immunology; Antibody; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009013664,0.0009416034,0.0008571237,0.001968645,0.0006911723,0.0009835702,0.0008849714,0.001579004,0.01087671],"category_scores_gemma":[0.0005297412,0.0007724741,0.0006598064,0.001067159,0.0005279857,0.0005337122,0.0007417798,0.002758202,0.006295886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003840502,"about_ca_system_score_gemma":0.0004303718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007497022,"about_ca_topic_score_gemma":0.001726429,"domain_scores_codex":[0.9991386,0.00007232818,0.0001067172,0.0002120654,0.0003176318,0.000152571],"domain_scores_gemma":[0.9992543,0.00009205964,0.0001414466,0.0001413097,0.0001229834,0.0002480488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001891949,0.0001329971,0.0001086475,0.00006400962,0.00001079548,0.0001086174,0.00004728271,0.00007435018,0.995787,0.0008506911,0.0005644231,0.002062001],"study_design_scores_gemma":[0.0001722583,0.0003043739,0.003129696,0.00005137628,0.00008190754,0.0006600033,0.00005185686,0.001204244,0.9554982,0.0004372172,0.03837439,0.00003462129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7833428,0.002891867,0.1467684,0.001342119,0.001681043,0.002064517,0.03753984,0.004095049,0.02027432],"genre_scores_gemma":[0.6587053,0.004549272,0.1551644,0.001180493,0.0002983589,0.003348542,0.03764277,0.004284382,0.1348264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01087671,"threshold_uncertainty_score":0.03638625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08473207355619318,"score_gpt":0.4167689759637931,"score_spread":0.3320369024076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}