{"id":"W4383198718","doi":"10.1371/journal.pgen.1010795","title":"ZCCHC3 is a stress granule zinc knuckle protein that strongly suppresses LINE-1 retrotransposition","year":2023,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Child Health and Human Development; National Institute of General Medical Sciences; Johns Hopkins Bloomberg School of Public Health; National Institute on Aging; National Cancer Institute; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Brock University; Johns Hopkins University","keywords":"Retrotransposon; Biology; Stress granule; Zinc finger; Ribonucleoprotein; Genetics; RNA; ORFS; Cell biology; Translation (biology); Genome; Gene; Transcription factor; Open reading frame; Messenger RNA; Transposable element; Peptide sequence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000490745,0.0002186482,0.0001338331,0.0001437353,0.0001620844,0.0002012498,0.0001514543,0.0002522584,0.0007404161],"category_scores_gemma":[0.00007479286,0.00006354691,0.0001782691,0.0001129544,0.0001814662,0.00008701788,0.0001352713,0.0002650956,0.0002827882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003436407,"about_ca_system_score_gemma":0.0001575713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007184104,"about_ca_topic_score_gemma":0.001137088,"domain_scores_codex":[0.9999387,0.000005678944,0.000003895707,0.00001520878,0.00002110956,0.000015408],"domain_scores_gemma":[0.9999186,0.00001515693,0.0000285093,0.000006496025,0.000006825653,0.00002443801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004541802,0.000007318697,0.0003742879,0.00001126763,0.000003126699,0.00004359714,0.000003311517,0.0000310331,0.9988932,0.0000348252,0.00003897519,0.0005137789],"study_design_scores_gemma":[0.00001853184,0.0001602428,0.01231554,0.000003743818,0.00001230521,0.0008321023,0.0000175392,0.001522401,0.9814316,0.00006507213,0.003616458,0.000004525062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954537,0.0008234396,0.002358433,0.00008888391,0.00001407787,0.00001567909,0.0004173622,0.0001172319,0.0007111466],"genre_scores_gemma":[0.9967186,0.0002267572,0.00121435,0.00005250409,0.000005714517,0.000009178851,0.000702973,0.00001982842,0.001050165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007404161,"threshold_uncertainty_score":0.002493262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04108415761069344,"score_gpt":0.2281000527308844,"score_spread":0.187015895120191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}