{"id":"W4383199379","doi":"10.1200/jco.23.00759","title":"Sequencing of Endocrine and Targeted Therapies in Hormone-Sensitive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer","year":2023,"lang":"en","type":"review","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Metastatic breast cancer; Breast cancer; Context (archaeology); Clinical trial; Cancer; Oncology; Population; Palbociclib; Letrozole; Targeted therapy; Internal medicine; Bioinformatics; Aromatase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005842683,0.0003641885,0.0003616938,0.0006713236,0.0005600549,0.0006735342,0.0004462198,0.001224314,0.001248595],"category_scores_gemma":[0.00286835,0.0002134621,0.0003436643,0.0005310223,0.0004874478,0.0007207642,0.000450284,0.001078363,0.0003990306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006452285,"about_ca_system_score_gemma":0.0006091537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009865731,"about_ca_topic_score_gemma":0.002037459,"domain_scores_codex":[0.9995669,0.0001284288,0.0000756924,0.00006609833,0.000109927,0.00005290752],"domain_scores_gemma":[0.9988924,0.000688268,0.000150883,0.0000383851,0.00009806888,0.0001320058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001071736,0.000231892,0.05184466,0.0007187118,0.00006583339,0.5359532,0.001836173,0.006582354,0.05538147,0.003924608,0.02017722,0.3222121],"study_design_scores_gemma":[0.00009515276,0.001375307,0.03209914,0.0006072989,0.000173513,0.777913,0.001993728,0.01567551,0.05001636,0.01023113,0.109727,0.00009287278],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.857474,0.0346733,0.03316831,0.03970268,0.001559274,0.0004560819,0.0005796867,0.0005140586,0.03187263],"genre_scores_gemma":[0.9405237,0.01865269,0.0245676,0.009830204,0.001250402,0.0001302441,0.00041907,0.00013673,0.004489428],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001248595,"threshold_uncertainty_score":0.004681528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1850355070904031,"score_gpt":0.5029483626875648,"score_spread":0.3179128555971616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}