{"id":"W4383216565","doi":"10.1016/j.actbio.2023.06.045","title":"An in vitro autologous, vascularized, and immunocompetent Tissue Engineered Skin model obtained by the self-assembled approach","year":2023,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Fonds de Recherche du Québec - Santé; Mitacs","keywords":"Dermis; Immune system; Flow cytometry; In vitro; Cell type; Immunology; Cell; Epidermis (zoology); Tissue engineering; Skin equivalent; Cell biology; Biology; Pathology; Medicine; Keratinocyte; Biomedical engineering; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002959125,0.0002218111,0.0002249003,0.00005683239,0.00009383525,0.00009983702,0.0003089858,0.0002248483,0.000002559462],"category_scores_gemma":[0.000008637537,0.0001733736,0.0000528319,0.000151524,0.00003137364,0.000008676652,0.00008106381,0.00005373422,0.00000369217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001702734,"about_ca_system_score_gemma":0.00004137934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001956654,"about_ca_topic_score_gemma":0.000009922052,"domain_scores_codex":[0.9987899,0.0001158604,0.000246398,0.0003998791,0.0001069639,0.0003409724],"domain_scores_gemma":[0.9994208,0.000006385465,0.00004737159,0.000432699,0.00002525491,0.0000675382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000172969,0.0001148475,0.00002809857,0.00003048135,0.00006501212,0.000003149101,0.0002081635,0.00006375131,0.998471,0.00001796388,0.0004292547,0.0003953585],"study_design_scores_gemma":[0.001214176,0.0000986032,0.0006121617,0.000003889535,0.00002652037,0.00001861184,0.00005864904,0.03152695,0.964393,0.00003080276,0.001772886,0.0002437969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978821,0.0001404661,0.00103043,0.0001418455,0.0002789639,0.000342029,0.00004966942,0.00009990221,0.00003459858],"genre_scores_gemma":[0.9966043,0.0001245601,0.002116199,0.00007266372,0.00008227498,0.00007448433,0.0008211373,0.00004003843,0.00006432159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.034078,"threshold_uncertainty_score":0.706997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008615083943709322,"score_gpt":0.2255474132824692,"score_spread":0.2169323293387598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}