{"id":"W4383216835","doi":"10.1016/j.jhep.2023.06.018","title":"Palliative clinical trials in advanced chronic liver disease: Challenges and opportunities","year":2023,"lang":"en","type":"review","venue":"Journal of Hepatology","topic":"Palliative Care and End-of-Life Issues","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Marie Curie; National Institute for Health and Care Research; Patient-Centered Outcomes Research Institute; National Institutes of Health; American Association for the Study of Liver Diseases; Cambia Health Foundation; University of Manitoba; Massachusetts General Hospital","keywords":"Medicine; Palliative care; Psychological intervention; Intensive care medicine; Disease; Clinical trial; Chronic liver disease; Liver disease; Chronic disease; Nursing; Internal medicine; Cirrhosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004331628,0.0003061042,0.00712318,0.0005570488,0.00001435608,0.000003997149,0.000153827,0.0004036271,0.00004253345],"category_scores_gemma":[0.007372432,0.0002053127,0.001019267,0.0001024782,0.0002569994,0.00006780944,0.00007563972,0.0007928089,0.000008765608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001554612,"about_ca_system_score_gemma":0.001606266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004235771,"about_ca_topic_score_gemma":0.00004383176,"domain_scores_codex":[0.9935369,0.002491297,0.003234049,0.0002461416,0.0002483908,0.0002432146],"domain_scores_gemma":[0.9889385,0.007489318,0.002847823,0.0002007541,0.0002420349,0.0002816351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002887887,0.0001010663,0.001815137,0.02214419,0.000936034,0.002859015,0.0002409087,1.234022e-7,6.997117e-8,0.0002982357,0.0005530482,0.9707634],"study_design_scores_gemma":[0.001543877,0.0009120558,0.001052006,0.06885261,0.002247729,0.0001412638,0.0002149022,0.000005153885,3.744204e-7,0.0002112578,0.9246588,0.0001599321],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006415482,0.9973907,0.000005569425,0.0007892757,0.0005859509,0.0004278374,0.00003658727,0.000009209063,0.0001133419],"genre_scores_gemma":[0.00008696587,0.9987999,0.000191114,0.00006868519,0.000634112,0.00002024425,0.00002100308,0.00003749919,0.0001405418],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9706035,"threshold_uncertainty_score":0.8826022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8322304476198072,"score_gpt":0.623039251259591,"score_spread":0.2091911963602162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}