{"id":"W4383217072","doi":"10.1093/braincomms/fcad195","title":"Longitudinal changes in hippocampal texture from healthy aging to Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"Brain Communications","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; Eisai Incorporated; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Takeda Pharmaceutical Company; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Merck; Alzheimer's Drug Discovery Foundation; Janssen Alzheimer Immunotherapy Research And Development; AbbVie; Fujirebio Europe; Alzheimer's Association; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Hippocampal formation; Neuroimaging; Dementia; Neuroscience; Alzheimer's disease; Psychology; Neuropathology; Hippocampus; Cognitive decline; Atrophy; Cognition; Disease; Medicine; Pathology; Audiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000153041,0.0001143804,0.0001629083,0.0002305966,0.000201245,0.0000178212,0.0004610028,0.00003389378,0.00002930076],"category_scores_gemma":[0.0001668212,0.0001201663,0.00004219837,0.0009329628,0.0000754935,0.00004480867,0.000399546,0.0002924035,0.0001290034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005017017,"about_ca_system_score_gemma":0.00007126544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001529878,"about_ca_topic_score_gemma":0.0004168561,"domain_scores_codex":[0.9991035,0.00006512211,0.0001864725,0.0002782124,0.0001268315,0.0002398641],"domain_scores_gemma":[0.9973536,0.0004232982,0.00004735633,0.001891571,0.000044254,0.0002399628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003137227,0.00156151,0.5110502,0.0001015592,0.0001242688,0.0001416796,0.003529677,0.000299716,0.008311553,0.03108141,0.2441733,0.1993113],"study_design_scores_gemma":[0.0005009096,0.00006465001,0.7515287,0.0002140995,0.00005650956,0.00000613512,0.0001785771,0.0037592,0.0001182265,0.007777241,0.2355746,0.0002211968],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.08297447,0.001581485,0.003014026,0.9088848,0.00004715573,0.00137869,0.0002015832,0.001060372,0.0008574761],"genre_scores_gemma":[0.9691296,0.0006263625,0.01754555,0.01119766,0.00008604303,0.0006598572,0.0005349297,0.00003575676,0.0001842635],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8976871,"threshold_uncertainty_score":0.4900238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2447787720848473,"score_gpt":0.451645994272378,"score_spread":0.2068672221875307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}