{"id":"W4383222993","doi":"10.1002/ange.202306272","title":"A Fluorogenic DNAzyme for A Thermally Stable Protein Biomarker from <i>Fusobacterium nucleatum</i>, a Human Bacterial Pathogen","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Fusobacterium nucleatum; Pathogen; Saliva; Biomarker; Human pathogen; Computational biology; Chemistry; Biology; Microbiology; Biochemistry; Bacteria; Genetics; Porphyromonas gingivalis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003369286,0.0006075928,0.0002098471,0.0002857807,0.0001532194,0.0002027245,0.0003635981,0.0006968377,0.0010905],"category_scores_gemma":[0.000494902,0.0001689428,0.000266073,0.0002051045,0.0003050626,0.000198437,0.0001947322,0.0004567532,0.0005156051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004035575,"about_ca_system_score_gemma":0.0002275943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004571915,"about_ca_topic_score_gemma":0.0004752727,"domain_scores_codex":[0.9997216,0.0000600571,0.00001755455,0.0001033336,0.00005946046,0.00003806133],"domain_scores_gemma":[0.9997067,0.00009291329,0.00008335807,0.00002499979,0.00005054664,0.00004153165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002035703,0.000007045865,0.0000676684,0.00002919015,0.000002116234,0.00002077219,0.000007514496,0.00004661785,0.9987362,0.00007794092,0.00003144869,0.0009530883],"study_design_scores_gemma":[0.000003437942,0.00005660751,0.0002851155,0.000003735739,0.000003321501,0.00007790596,0.000003772148,0.0003063309,0.9983416,0.00001246262,0.0009033212,0.000002372702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8310304,0.003323273,0.1580207,0.000527703,0.0002252074,0.0002297471,0.0006342681,0.0005739832,0.00543468],"genre_scores_gemma":[0.9043394,0.0008804596,0.08763964,0.0002657071,0.00002407438,0.0002219471,0.000781976,0.00004685797,0.005799932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010905,"threshold_uncertainty_score":0.003648102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948435822152505,"score_gpt":0.2683712452563661,"score_spread":0.2488868870348411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}