{"id":"W4383226457","doi":"10.1136/jme-2023-109061","title":"Guerrilla eugenics: gene drives in heritable human genome editing","year":2023,"lang":"en","type":"article","venue":"Journal of Medical Ethics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Genome editing; Eugenics; CRISPR; Genome; Bioethics; Genetics; Biology; Human genome; Human genetics; Cas9; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01551789,0.000381407,0.000404913,0.0005086571,0.002278364,0.004050233,0.001033997,0.006984921,0.001947417],"category_scores_gemma":[0.02357437,0.0002995532,0.0004971107,0.0004200263,0.01781164,0.003583591,0.005102691,0.008095017,0.0006976015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001809192,"about_ca_system_score_gemma":0.002358427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00150172,"about_ca_topic_score_gemma":0.002494832,"domain_scores_codex":[0.9871689,0.007740998,0.0004451345,0.001047314,0.003023911,0.0005736566],"domain_scores_gemma":[0.9870338,0.009722665,0.001072493,0.001315157,0.0004793581,0.000376502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0000273451,0.00001384232,0.0004986558,0.0001010732,0.00001085222,0.0002877509,0.001654751,0.0003193976,0.001306067,0.9586856,0.01083497,0.02625973],"study_design_scores_gemma":[0.00002651239,0.0001364843,0.001049683,0.0006704837,0.00003547905,0.002127588,0.0009882046,0.001267815,0.006007697,0.5029998,0.4846144,0.00007583251],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.03877971,0.02447398,0.1985338,0.3619851,0.005916939,0.0002686391,0.000153682,0.0007861399,0.3691021],"genre_scores_gemma":[0.6394714,0.01450617,0.107465,0.1678653,0.001915773,0.0007127518,0.00009854522,0.000249427,0.06771562],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01551789,"threshold_uncertainty_score":0.08206743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.024889606380148,"score_gpt":0.3825037551490578,"score_spread":0.3576141487689097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}