{"id":"W4383262960","doi":"10.3390/cancers15133493","title":"Targeted Alpha Therapy (TAT) with Single-Domain Antibodies (Nanobodies)","year":2023,"lang":"en","type":"review","venue":"Cancers","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Canadian Nuclear Laboratories","funders":"","keywords":"Antibody; Antigen; Targeted therapy; Single-domain antibody; Cancer research; Cancer; Chemistry; Molecular biology; Medicine; Immunology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002296483,0.0004579389,0.0004537459,0.0006084238,0.0001420289,0.0004598693,0.0003816123,0.0004870965,0.001085239],"category_scores_gemma":[0.0001797666,0.0001467713,0.0003536776,0.0004371452,0.0002941315,0.0004421382,0.0003206815,0.0005723787,0.0009226464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003453167,"about_ca_system_score_gemma":0.0002460442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000265543,"about_ca_topic_score_gemma":0.0003116246,"domain_scores_codex":[0.9998642,0.00002218996,0.000009975701,0.00003444609,0.00005109733,0.00001801119],"domain_scores_gemma":[0.9999466,0.00002019376,0.00001474658,0.000003183307,0.00001012169,0.000005109747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000200538,0.0001318853,0.0005120004,0.008057705,0.0001302394,0.0005061826,0.0001537475,0.001241943,0.4135759,0.01225771,0.009796267,0.5534359],"study_design_scores_gemma":[0.00003489369,0.001028172,0.0009648291,0.0004063388,0.0001674286,0.003500682,0.00006263022,0.001330181,0.225178,0.002659298,0.7646325,0.00003502195],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01847589,0.9493291,0.02154788,0.0005380287,0.0007036044,0.00005863518,0.0001026602,0.0002836869,0.008960524],"genre_scores_gemma":[0.1017623,0.8768817,0.01085198,0.0008601011,0.0005132669,0.0001365297,0.0002636239,0.00004785657,0.008682593],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001085239,"threshold_uncertainty_score":0.003630519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1306533572997492,"score_gpt":0.3905217188737084,"score_spread":0.2598683615739592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}