{"id":"W4383264311","doi":"10.1038/s41467-023-39132-x","title":"Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based high-throughput platform","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"G protein-coupled receptor; Druggability; Computational biology; Internalization; Agonist; Receptor; Drug discovery; Biology; Functional selectivity; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001929117,0.00009636424,0.0001412183,0.00005336678,0.00009695558,0.000008989804,0.0003376733,0.0002234375,0.00000675142],"category_scores_gemma":[0.000032308,0.00009120654,0.00005135142,0.0001084086,0.0000897634,0.000005253961,0.0002179096,0.0002141054,5.592097e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008321311,"about_ca_system_score_gemma":0.00005563511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002437952,"about_ca_topic_score_gemma":0.00003583437,"domain_scores_codex":[0.9993728,0.00003968539,0.0001909744,0.0001468841,0.0001305366,0.0001190696],"domain_scores_gemma":[0.999085,0.00005909513,0.0001257961,0.0006363439,0.00006025084,0.00003350253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002376149,0.00006793544,0.0006688959,0.00003935323,0.00002893463,1.064603e-7,0.00007609967,0.00007844037,0.9974557,0.0008125451,0.0005468689,0.0002013534],"study_design_scores_gemma":[0.0003291106,0.0001099462,0.0001149952,0.00002264825,0.00001984086,4.697707e-7,0.0003746361,0.0006262945,0.9969342,0.0001070459,0.001270764,0.00008999045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928612,0.004753601,0.001298616,0.0002578491,0.00008385667,0.0001866501,0.0002119014,0.0000168346,0.0003295679],"genre_scores_gemma":[0.9937189,0.001317969,0.004237983,0.00006255753,0.00002047905,0.00002203574,0.0004973531,0.00001579317,0.0001069881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003435632,"threshold_uncertainty_score":0.3719295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328500598823044,"score_gpt":0.2675168043164851,"score_spread":0.2542317983282546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}