{"id":"W4383302397","doi":"10.1158/1541-7786.mcr-23-0086","title":"Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its Activity and Oncogenic Function in Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Terry Fox Research Institute; Génome Québec; McGill University; Canadian Institutes of Health Research; Cancer Research Society; Université Laval","keywords":"Prostate cancer; PI3K/AKT/mTOR pathway; Cancer research; Biology; Transcription factor; Cancer; Cell biology; Gene; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007865247,0.0001520761,0.000297649,0.0005012144,0.0001065652,0.00002841813,0.00009014515,0.0001028134,0.0001436849],"category_scores_gemma":[0.0001017744,0.0001283518,0.00006110695,0.00162555,0.0002548039,0.0001126013,0.0001378684,0.0005973426,0.00001750572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004504901,"about_ca_system_score_gemma":0.0006214645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002414568,"about_ca_topic_score_gemma":0.0001789961,"domain_scores_codex":[0.9974531,0.0002331506,0.00021353,0.0004735739,0.000989988,0.0006366724],"domain_scores_gemma":[0.999115,0.0001158322,0.00004492385,0.0002170131,0.0002965106,0.0002106743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003240756,0.0001573248,0.04558541,0.0004157607,0.000136844,0.0001290279,0.0004928435,0.0000413535,0.8942318,0.00003517708,0.001930324,0.05360337],"study_design_scores_gemma":[0.004349555,0.0009165547,0.1548693,0.0003894193,0.00004658541,0.000003495109,0.0001479911,0.002368503,0.8331714,0.0003507737,0.003199011,0.0001873251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791738,0.01493628,0.00001159387,0.004238484,0.00007001823,0.001203812,0.000113522,0.00004205855,0.000210362],"genre_scores_gemma":[0.9812599,0.01491788,0.00000956435,0.00003606511,0.00004164647,0.0008773938,0.00007676103,0.00004013694,0.002740626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1092839,"threshold_uncertainty_score":0.5234033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04432699187842464,"score_gpt":0.3893539751661464,"score_spread":0.3450269832877218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}