{"id":"W4383314786","doi":"10.1016/s0140-6736(23)00774-2","title":"First-line atezolizumab monotherapy versus single-agent chemotherapy in patients with non-small-cell lung cancer ineligible for treatment with a platinum-containing regimen (IPSOS): a phase 3, global, multicentre, open-label, randomised controlled study","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Atezolizumab; Medicine; Internal medicine; Regimen; Population; Chemotherapy regimen; Oncology; Chemotherapy; Vinorelbine; Clinical endpoint; Performance status; Lung cancer; Gemcitabine; Phases of clinical research; Cancer; Surgery; Clinical trial; Pembrolizumab; Immunotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004544441,0.0004677033,0.001490181,0.00009874345,0.0002088213,0.0001145325,0.0003626878,0.00007566732,0.00004795651],"category_scores_gemma":[0.00001868191,0.0002543071,0.0000981666,0.000642618,0.00006282168,0.00009857622,0.00003773308,0.0001000589,0.000002979982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008962681,"about_ca_system_score_gemma":0.0002712173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001511889,"about_ca_topic_score_gemma":0.002950434,"domain_scores_codex":[0.9978392,0.0001020125,0.0005287032,0.0005425663,0.0003176465,0.0006698789],"domain_scores_gemma":[0.9983945,0.0003422849,0.0003587315,0.0006660369,0.0001344051,0.0001040678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9328895,0.00638018,0.04044182,0.00007604739,0.002733666,0.00003280631,0.004859581,0.0004038579,0.0003872805,0.000001025542,0.0008730697,0.01092119],"study_design_scores_gemma":[0.9548538,0.02532904,0.005618946,0.0003820462,0.0006193597,0.000001226711,0.0008958665,0.01030229,0.0005070739,0.000002927958,0.001144813,0.0003426662],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771876,0.000743467,0.0001335727,0.001756295,0.0001536918,0.01954897,0.0001106794,0.0001049567,0.0002607382],"genre_scores_gemma":[0.9920684,0.0009440539,0.0005176975,0.0007827287,0.0002270423,0.004835903,0.0001031664,0.00008522569,0.0004357661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03482287,"threshold_uncertainty_score":0.9999909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05724716795188822,"score_gpt":0.3473963572473626,"score_spread":0.2901491892954744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}