{"id":"W4383337813","doi":"10.1371/journal.pmed.1004247","title":"Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals","year":2023,"lang":"en","type":"review","venue":"PLoS Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Chief Scientist Office, Scottish Government Health and Social Care Directorate; University of Edinburgh; European Commission; Eli Lilly and Company; UK Research and Innovation; Alzheimer Society; Wellcome Trust; Alzheimer's Society; Scottish Government; British Heart Foundation; Horizon 2020 Framework Programme; Scottish Funding Council; Helsingin Yliopisto; Wellcome","keywords":"Medicine; CpG site; DNA methylation; Population; Cohort; Disease; Epigenome; Cohort study; Epigenetics; Internal medicine; Oncology; Genetics; Biology; Environmental health","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001790821,0.0005015291,0.0004503973,0.00096709,0.0009957867,0.000698074,0.0006018012,0.0005185928,0.001085804],"category_scores_gemma":[0.002464317,0.0004440539,0.001017857,0.001572809,0.0004686695,0.000406014,0.001035284,0.0006984566,0.0002685722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007675501,"about_ca_system_score_gemma":0.001044974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.07592128,"about_ca_topic_score_gemma":0.08249571,"domain_scores_codex":[0.9991866,0.0001819564,0.00007714034,0.0002493578,0.0001659026,0.0001389502],"domain_scores_gemma":[0.9982988,0.0001799266,0.0004447599,0.0003591516,0.0003672602,0.0003501172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002266107,0.0000582127,0.9953538,0.00001294382,0.0002175695,0.0002361368,0.0003821145,0.00005162315,0.001082239,0.00002783126,0.0003180463,0.002033044],"study_design_scores_gemma":[0.00003021975,0.00009634667,0.9989343,0.000005206723,0.00006696396,0.0001743226,0.0001490584,0.0001218864,0.00008021503,0.00001745206,0.0003177593,0.000006274945],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980363,0.00007289438,0.0002474244,0.00003193513,0.000004421734,0.00002350448,0.001434509,0.000007534689,0.0001414741],"genre_scores_gemma":[0.9968773,0.0001114852,0.0006132639,0.0000930339,0.00001087038,0.0000484892,0.001921878,0.000005489673,0.000318211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07592128,"threshold_uncertainty_score":0.1509588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1344486249916879,"score_gpt":0.4085692079994535,"score_spread":0.2741205830077655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}