{"id":"W4383337813","doi":"10.1371/journal.pmed.1004247","title":"Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals","year":2023,"lang":"en","type":"review","venue":"PLoS Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Chief Scientist Office, Scottish Government Health and Social Care Directorate; University of Edinburgh; European Commission; Eli Lilly and Company; UK Research and Innovation; Alzheimer Society; Wellcome Trust; Alzheimer's Society; Scottish Government; British Heart Foundation; Horizon 2020 Framework Programme; Scottish Funding Council; Helsingin Yliopisto; Wellcome","keywords":"Medicine; CpG site; DNA methylation; Population; Cohort; Disease; Epigenome; Cohort study; Epigenetics; Internal medicine; Oncology; Genetics; Biology; Environmental health","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009201079,0.0005452859,0.00238628,0.0005526021,0.00008370423,0.00001295731,0.0004543564,0.0002904188,0.00006426592],"category_scores_gemma":[0.001464465,0.0004437162,0.0003737192,0.0007731171,0.000159544,0.000003344813,0.000111615,0.0002199843,0.000003519855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003965139,"about_ca_system_score_gemma":0.0004799487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001096465,"about_ca_topic_score_gemma":0.0002040128,"domain_scores_codex":[0.9956638,0.0005863151,0.001819325,0.0007753232,0.0008416234,0.0003135866],"domain_scores_gemma":[0.9960651,0.0006065784,0.001552498,0.00114163,0.0003345615,0.0002995674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005868789,0.001643739,0.9722611,0.01699532,0.0028042,0.00003031357,0.00004778445,0.001517008,0.0003471382,0.000001034463,0.0001643136,0.004129326],"study_design_scores_gemma":[0.01129153,0.01123818,0.8033028,0.04784902,0.07782757,0.000001142673,0.0002856567,0.0006304353,0.002998939,0.0002645663,0.04112683,0.003183368],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2779907,0.7192186,0.0001202736,0.0000243326,0.00009691864,0.002112639,0.0003950436,0.00002356962,0.00001793706],"genre_scores_gemma":[0.220242,0.7664683,0.000111731,0.00004021851,0.0002273925,0.000259584,0.01246307,0.0001163906,0.00007124223],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1689584,"threshold_uncertainty_score":0.9998015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1344486249916879,"score_gpt":0.4085692079994535,"score_spread":0.2741205830077655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}