{"id":"W4383341159","doi":"10.1038/s41591-023-02453-x","title":"Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial","year":2023,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":451,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; Université de Montréal; St Joseph's Health Care; Jewish General Hospital; Lawson Health Research Institute; Western University; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Medical Research Council; Canadian Institutes of Health Research; Agence Nationale de la Recherche; Lotte and John Hecht Memorial Foundation","keywords":"Pembrolizumab; Nivolumab; Medicine; Transplantation; Adverse effect; Microbiome; Clinical endpoint; Melanoma; Fecal bacteriotherapy; Internal medicine; Immune system; Oncology; Immunology; Immunotherapy; Clinical trial; Clostridium difficile; Cancer research; Bioinformatics; Biology; Antibiotics; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006776542,0.001224938,0.001910061,0.0002779228,0.0003881181,0.0009857208,0.0005422007,0.001065118,0.003274936],"category_scores_gemma":[0.000473251,0.0003299812,0.001513621,0.0003037358,0.0007303258,0.0008057837,0.0003193698,0.00349985,0.0007235232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007163191,"about_ca_system_score_gemma":0.0008210079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007223492,"about_ca_topic_score_gemma":0.001902246,"domain_scores_codex":[0.9998208,0.00005154651,0.000006913528,0.00003719082,0.00001488156,0.00006868829],"domain_scores_gemma":[0.9997572,0.00003783899,0.00004129607,0.00002211053,0.00001493781,0.0001265948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5674333,0.05852042,0.003194754,0.002320138,0.002692706,0.0002682465,0.0002271627,0.004002271,0.02950178,0.0008198767,0.009579099,0.3214403],"study_design_scores_gemma":[0.5948246,0.3891509,0.005487274,0.0002033714,0.001016516,0.0002543363,0.0001089778,0.001463323,0.002802941,0.0006624633,0.003991736,0.00003354837],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822923,0.009535049,0.0007787804,0.001580465,0.0007666455,0.001455064,0.0006168955,0.0001592624,0.002815506],"genre_scores_gemma":[0.9830849,0.006632912,0.001277198,0.001856472,0.0003184016,0.001614216,0.001030974,0.00003284102,0.004152201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003274936,"threshold_uncertainty_score":0.01095581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008649303905333567,"score_gpt":0.3372676309556855,"score_spread":0.3286183270503519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}