{"id":"W4383341159","doi":"10.1038/s41591-023-02453-x","title":"Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial","year":2023,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":451,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; Université de Montréal; St Joseph's Health Care; Jewish General Hospital; Lawson Health Research Institute; Western University; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Medical Research Council; Canadian Institutes of Health Research; Agence Nationale de la Recherche; Lotte and John Hecht Memorial Foundation","keywords":"Pembrolizumab; Nivolumab; Medicine; Transplantation; Adverse effect; Microbiome; Clinical endpoint; Melanoma; Fecal bacteriotherapy; Internal medicine; Immune system; Oncology; Immunology; Immunotherapy; Clinical trial; Clostridium difficile; Cancer research; Bioinformatics; Biology; Antibiotics; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003225212,0.0001693119,0.0002784622,0.0001564107,0.00005542315,0.000005285883,0.0001495934,0.0004295883,0.00004351838],"category_scores_gemma":[0.0000449845,0.000137755,0.00005807382,0.0003455652,0.00006811191,0.000003540624,0.00001481392,0.0003753814,0.00001479034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003268315,"about_ca_system_score_gemma":0.000116838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003324254,"about_ca_topic_score_gemma":0.00009959596,"domain_scores_codex":[0.9988813,0.00006751679,0.0002903792,0.0003439704,0.0001126316,0.0003041389],"domain_scores_gemma":[0.9995784,0.00002176679,0.00007132092,0.0002270555,0.00003944145,0.00006197751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01144225,0.00007884186,0.00008740257,0.00005211825,0.00001951624,0.00004192672,0.0002761185,0.000007187577,0.9813762,0.00002481602,0.003911046,0.002682524],"study_design_scores_gemma":[0.4668113,0.006008468,0.02558759,0.0003596536,0.00006683984,0.000172641,0.0003933761,0.00008280262,0.3300919,0.00006708487,0.1696563,0.0007020554],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930011,0.003270266,0.00009836505,0.001889976,0.0008543679,0.0005448975,0.0000458718,0.00003051306,0.0002646359],"genre_scores_gemma":[0.9933254,0.002930869,0.0001152613,0.001101625,0.0005759503,0.00002041589,0.001495723,0.00002516185,0.0004096083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6512843,"threshold_uncertainty_score":0.5617487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008649303905333567,"score_gpt":0.3372676309556855,"score_spread":0.3286183270503519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}