{"id":"W4383342182","doi":"10.1021/acsmaterialsau.3c00029","title":"Engineered In Vitro Tumor Model Recapitulates Molecular Signatures of Invasion in Glioblastoma","year":2023,"lang":"en","type":"article","venue":"ACS Materials Au","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Amgen; Amgen Foundation","keywords":"Extracellular matrix; Gene knockdown; Cell biology; Downregulation and upregulation; Focal adhesion; In vitro; Mesenchymal stem cell; Biology; Cancer research; Cell culture; Stem cell; Signal transduction; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002043287,0.0001128831,0.000171834,0.0001583469,0.0000133571,0.00001245776,0.0001273453,0.0001087253,0.0000160866],"category_scores_gemma":[0.00008962832,0.0001141248,0.00003947943,0.0001655749,0.00001230324,0.000005100819,0.0001123552,0.00005370479,0.00001099307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001878234,"about_ca_system_score_gemma":0.00005053133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009722128,"about_ca_topic_score_gemma":0.00005392531,"domain_scores_codex":[0.9991996,0.00004150072,0.0002673599,0.0002145559,0.00007885113,0.0001981532],"domain_scores_gemma":[0.9996511,0.000008852167,0.00006493947,0.0002172094,0.00003000817,0.00002787473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001578664,0.00003760529,0.000007570911,0.00002817418,0.000008652078,0.00001676635,0.00005091886,0.004913046,0.9944484,0.0001572528,0.0001146405,0.00005913737],"study_design_scores_gemma":[0.0003118593,0.00007852516,0.0001326064,0.00003379246,0.000003761382,0.000002879819,0.00002847317,0.002933093,0.9957647,0.000473347,0.0001228863,0.0001140627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999305,0.00008838854,0.0001254973,0.00004932503,0.0001884154,0.0001382246,0.00004727954,0.0000115595,0.00004637678],"genre_scores_gemma":[0.9994272,0.00006972326,0.0001446458,0.00004918562,0.00003362766,0.00002699793,0.0001552195,0.00002312263,0.0000702581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001979952,"threshold_uncertainty_score":0.4653873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008063295732202398,"score_gpt":0.2299078276106874,"score_spread":0.221844531878485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}