{"id":"W4383368896","doi":"10.3390/metabo13070826","title":"mGWAS-Explorer 2.0: Causal Analysis and Interpretation of Metabolite–Phenotype Associations","year":2023,"lang":"en","type":"article","venue":"Metabolites","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Genome Canada","keywords":"Phenotype; Quantitative trait locus; Metabolomics; Context (archaeology); Biology; Single-nucleotide polymorphism; Computational biology; Genetic association; Genetics; Trait; Bioinformatics; Gene; Genotype; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004263045,0.0001474972,0.0004182993,0.0003911236,0.00007806901,0.0000242466,0.0001058819,0.0000801509,0.00001677028],"category_scores_gemma":[0.0004474015,0.0001323409,0.0001818792,0.001214781,0.00007562903,0.000007916735,0.0001440341,0.00005606136,0.000008843942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004775757,"about_ca_system_score_gemma":0.00002116459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004165981,"about_ca_topic_score_gemma":0.00003561892,"domain_scores_codex":[0.9989129,0.00008881446,0.0003004656,0.0003097609,0.0001623809,0.0002257193],"domain_scores_gemma":[0.9993265,0.00005109956,0.0001547029,0.000260999,0.0001601586,0.00004653968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005154685,0.00006750885,0.1275157,0.00002887867,0.004224449,9.197241e-7,0.000667522,0.0001124076,0.8498353,0.009236341,0.0006741789,0.007585142],"study_design_scores_gemma":[0.0004559397,0.00008308414,0.7604134,0.000002983726,0.001967838,6.323748e-7,0.0005221101,0.001332927,0.2149923,0.00201043,0.01790954,0.0003087899],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876874,0.008651368,0.002261382,0.0001639923,0.0001617103,0.0001164931,0.0002191397,0.00004098046,0.000697508],"genre_scores_gemma":[0.9945442,0.002915757,0.00141277,0.00005011614,0.00008286148,0.0000234153,0.000499952,0.00001579131,0.0004551356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6348431,"threshold_uncertainty_score":0.5396703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206889301646155,"score_gpt":0.2686315681493854,"score_spread":0.2565626751329239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}