{"id":"W4383371746","doi":"10.1016/j.cmi.2023.07.004","title":"A pilot phase 2a, randomized, double-blind, placebo-controlled study to explore the antiviral activity, clinical outcomes, safety, and tolerability of rilematovir at two dose levels in non-hospitalized adults with respiratory syncytial virus infection","year":2023,"lang":"en","type":"article","venue":"Clinical Microbiology and Infection","topic":"Respiratory viral infections research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Etobicoke General Hospital","funders":"Janssen Pharmaceuticals; Janssen Research and Development","keywords":"Medicine; Tolerability; Placebo; Internal medicine; Viral load; Clinical trial; Adverse effect; Randomized controlled trial; Gastroenterology; Virus; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003359782,0.002525286,0.004819074,0.0005780355,0.0009666295,0.001313385,0.001437053,0.002913847,0.007179124],"category_scores_gemma":[0.003192026,0.001221212,0.002532517,0.0005248644,0.002333808,0.001996997,0.0006457801,0.004678908,0.001273285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008345291,"about_ca_system_score_gemma":0.002258276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001406424,"about_ca_topic_score_gemma":0.002464301,"domain_scores_codex":[0.9984599,0.0007881006,0.00009954791,0.0002810105,0.00009185215,0.0002795153],"domain_scores_gemma":[0.9975453,0.000680291,0.0003773592,0.0003225832,0.0002323901,0.0008421151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9638891,0.02456881,0.0005050968,0.0002590905,0.0004181061,0.00004161002,0.00007196139,0.0001485811,0.004662727,0.00006527101,0.0004516866,0.004918],"study_design_scores_gemma":[0.8523986,0.1455427,0.001237025,0.000008161751,0.0001276693,0.00001663704,0.00002011283,0.0001070494,0.0002757815,0.00005732575,0.0001982593,0.00001068543],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825202,0.001150859,0.001185901,0.0005523137,0.0004913101,0.01110644,0.001546561,0.0001713274,0.001275174],"genre_scores_gemma":[0.9700038,0.0009698403,0.004666789,0.002158626,0.0007921322,0.01657953,0.002208244,0.00005134802,0.002569869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007179124,"threshold_uncertainty_score":0.0240165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.147858085042014,"score_gpt":0.4746326403901559,"score_spread":0.3267745553481419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}