{"id":"W4383376466","doi":"10.1101/2023.07.05.547863","title":"A genetic code change in progress: tRNA-Leu(CAG) is conserved in most <i>Saccharomycopsis</i> yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"","keywords":"Biology; Transfer RNA; Gene; Genetics; Genetic code; Translation (biology); Codon usage bias; Genome; RNA; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001080425,0.0003815088,0.000286695,0.0003497399,0.0003049457,0.0004966856,0.000192678,0.0003451603,0.0009551752],"category_scores_gemma":[0.0002909862,0.0001094624,0.0003972012,0.0004276897,0.0002384301,0.0002162453,0.0002292886,0.0003403511,0.0004113253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002502536,"about_ca_system_score_gemma":0.0002448759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007401715,"about_ca_topic_score_gemma":0.0009344349,"domain_scores_codex":[0.999873,0.0000133922,0.00001272782,0.00004432177,0.00003391303,0.00002255229],"domain_scores_gemma":[0.9995938,0.00006307317,0.0001567021,0.00005525579,0.00005025702,0.00008085836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001321691,0.00001500163,0.006172852,0.000058872,0.00001229334,0.0003722055,0.00003717765,0.00008046364,0.9907521,0.0001088178,0.00006991782,0.002188049],"study_design_scores_gemma":[0.00003847372,0.0005437675,0.1872171,0.00004883203,0.0001603797,0.004192092,0.0004180766,0.003911064,0.7910771,0.0002980717,0.01204622,0.00004878669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951727,0.0004273802,0.002735374,0.00004876938,0.00003437801,0.00001612873,0.0006630779,0.0001533461,0.0007488299],"genre_scores_gemma":[0.9955541,0.000109431,0.002405815,0.00004406345,0.000008336545,0.00001152994,0.001256969,0.00004231108,0.0005674218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009551752,"threshold_uncertainty_score":0.003195345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02200953152338777,"score_gpt":0.2284470473831998,"score_spread":0.2064375158598121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}