{"id":"W4383483549","doi":"10.1038/s41419-023-05921-x","title":"Sumoylated SnoN interacts with HDAC1 and p300/CBP to regulate EMT-associated phenotypes in mammary organoids","year":2023,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; U.S. Department of Health and Human Services; Breast Cancer Society of Canada; National Institutes of Health; University of Calgary","keywords":"SUMO protein; HDAC1; Cell biology; Biology; Histone deacetylase; Wnt signaling pathway; Epithelial–mesenchymal transition; Acetylation; Epigenetics; Cancer research; Histone; Ubiquitin; Metastasis; Signal transduction; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009768931,0.0002667959,0.0002299158,0.0002020934,0.0001736317,0.0002773423,0.0002473536,0.0001540608,0.0008049537],"category_scores_gemma":[0.00007876416,0.0001559571,0.0002304509,0.0001207418,0.0001949675,0.0001635303,0.0002698177,0.0003500903,0.0004296551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00063334,"about_ca_system_score_gemma":0.0002258298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001307697,"about_ca_topic_score_gemma":0.002932061,"domain_scores_codex":[0.9999052,0.00001294758,0.000006241175,0.00002197759,0.00002890424,0.00002476962],"domain_scores_gemma":[0.9999235,0.000009076623,0.00002035398,0.00001046606,0.00000927305,0.00002734008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005829931,0.000009706558,0.000194537,0.0000110399,0.000003182799,0.0000342067,0.00000840434,0.00004523352,0.9989035,0.00008075429,0.0000273161,0.0006236975],"study_design_scores_gemma":[0.000007415725,0.00005873591,0.00648395,0.000002471038,0.000007562694,0.0001176359,0.00003104631,0.001170172,0.9903321,0.00004635991,0.001739642,0.000002924297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991446,0.001973127,0.003826102,0.00009987217,0.00003313809,0.00001400219,0.0001990006,0.00008906124,0.002319697],"genre_scores_gemma":[0.9955236,0.0004492658,0.001006727,0.00003616401,0.000002824686,0.00001058236,0.0002624877,0.00001774241,0.002690601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001307697,"threshold_uncertainty_score":0.00459528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007779964390031594,"score_gpt":0.217158424757827,"score_spread":0.2093784603677954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}