{"id":"W4383483549","doi":"10.1038/s41419-023-05921-x","title":"Sumoylated SnoN interacts with HDAC1 and p300/CBP to regulate EMT-associated phenotypes in mammary organoids","year":2023,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; U.S. Department of Health and Human Services; Breast Cancer Society of Canada; National Institutes of Health; University of Calgary","keywords":"SUMO protein; HDAC1; Cell biology; Biology; Histone deacetylase; Wnt signaling pathway; Epithelial–mesenchymal transition; Acetylation; Epigenetics; Cancer research; Histone; Ubiquitin; Metastasis; Signal transduction; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101185,0.0001544867,0.0001262153,0.00008076894,0.00006014758,0.00004717704,0.00008245111,0.00008059516,0.00001233575],"category_scores_gemma":[0.00009396209,0.0001353327,0.00002209513,0.0001991702,0.0000275545,0.000007600055,0.0001394166,0.00006499635,0.00001586854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009181079,"about_ca_system_score_gemma":0.0000836658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002514253,"about_ca_topic_score_gemma":0.00003465614,"domain_scores_codex":[0.9991307,0.00004807813,0.0001182449,0.0003558673,0.00007770377,0.0002693897],"domain_scores_gemma":[0.999287,0.00001252071,0.00003322657,0.0001929798,0.00003731905,0.0004369164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003077989,0.0004440733,0.2569198,0.0004490724,0.0001108627,0.0007419675,0.0009923931,0.0001236543,0.7187402,0.000292,0.006004139,0.01210388],"study_design_scores_gemma":[0.004113291,0.0009511011,0.7693954,0.0002354551,0.00008690116,0.0000101735,0.0001594801,0.0008136706,0.2164444,0.001320783,0.005494677,0.0009745903],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975154,0.0007861585,0.00002850776,0.0002929968,0.0000339902,0.000240577,0.00004287942,0.00003826823,0.001021153],"genre_scores_gemma":[0.9970423,0.0002317113,0.00007456907,0.0004877736,0.00003589806,0.00002470829,0.000301234,0.00002233951,0.001779452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5124756,"threshold_uncertainty_score":0.5518708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007779964390031594,"score_gpt":0.217158424757827,"score_spread":0.2093784603677954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}