{"id":"W4383499691","doi":"10.1038/s41467-023-39690-0","title":"Signatures of VH1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteins","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Hepatitis C virus research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Institute of Infection and Immunity; Bill and Melinda Gates Foundation; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Amsterdam University Medical Centers","keywords":"Virology; Epitope; Glycoprotein; Antibody; Germline; Biology; Hepatitis C virus; Recombinant DNA; Virus; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013411,0.0001702603,0.00006786454,0.0001546945,0.00008843944,0.000201876,0.0001022802,0.0002018748,0.001260104],"category_scores_gemma":[0.0001417963,0.00008412815,0.0001023452,0.00005837198,0.0001042669,0.00008858047,0.0001284246,0.0002477496,0.0002628657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002269114,"about_ca_system_score_gemma":0.00008981687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005552592,"about_ca_topic_score_gemma":0.0005229326,"domain_scores_codex":[0.9999254,0.0000142275,0.000003508737,0.00001203107,0.00001796889,0.00002688579],"domain_scores_gemma":[0.9999207,0.00001675652,0.00002052106,0.000006000856,0.00001648335,0.0000196005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006244236,0.000007791637,0.0005250031,0.000007741905,0.000001543407,0.00002991127,0.00001360111,0.00005976052,0.9984649,0.0001171827,0.00002233507,0.0006876817],"study_design_scores_gemma":[0.00001850881,0.0004089618,0.01995667,0.000008091282,0.000009280471,0.0007231848,0.00008564492,0.003900032,0.972697,0.0001638425,0.002022857,0.000005838936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974561,0.000142242,0.00112274,0.00001596095,0.000003874682,0.000009621716,0.00004917759,0.00002147517,0.001178734],"genre_scores_gemma":[0.9980968,0.0000640444,0.001054859,0.00003618443,0.000002426951,0.000007196164,0.000116745,0.000007904707,0.0006139672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001260104,"threshold_uncertainty_score":0.004215479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04290187127170164,"score_gpt":0.3816466531379054,"score_spread":0.3387447818662037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}