{"id":"W4383500293","doi":"10.1101/2023.07.05.23292214","title":"Genetic structure of major depression symptoms across clinical and community cohorts","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Mental Health Research Topics","field":"Psychology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Medical Research Council; Rivierduinen; GGZ Drenthe; GGZ Friesland; Universitair Medisch Centrum Groningen; GGZ inGeest; National Health and Medical Research Council; Foundation for the National Institutes of Health; National Institutes of Health; Rijksuniversiteit Groningen; European Regional Development Fund; European Commission; Leids Universitair Medisch Centrum; Universiteit Leiden; Wellcome Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Vrije Universiteit Amsterdam","keywords":"Biobank; Anhedonia; Depression (economics); Major depressive disorder; Medicine; Clinical psychology; Psychiatry; Psychology; Schizophrenia (object-oriented programming); Bioinformatics; Biology; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008729063,0.0004955574,0.0006691757,0.001153538,0.0008220111,0.001367164,0.0009417941,0.000876539,0.00290335],"category_scores_gemma":[0.01866817,0.0004595378,0.001613423,0.001435097,0.0007547749,0.0004104751,0.001187822,0.0009862469,0.0002081993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005076968,"about_ca_system_score_gemma":0.0006723541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01190986,"about_ca_topic_score_gemma":0.01082521,"domain_scores_codex":[0.994013,0.003348153,0.0002894709,0.001624594,0.0004067085,0.0003180789],"domain_scores_gemma":[0.9899589,0.005227219,0.001650048,0.00190942,0.0007725863,0.0004817288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008340332,0.00008214215,0.9876171,0.00003567192,0.00251776,0.0001988105,0.0004730815,0.000902402,0.001826308,0.0006747804,0.0005821313,0.00425586],"study_design_scores_gemma":[0.000107606,0.000181345,0.9932358,0.00002787092,0.0007204093,0.0002766209,0.0003508182,0.003300116,0.0002638616,0.001227419,0.0002899311,0.00001817599],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969293,0.0002567915,0.001629578,0.0001794878,0.00001426102,0.00002387119,0.0005156209,0.00002543727,0.0004255834],"genre_scores_gemma":[0.9984849,0.00004933335,0.0007626416,0.00004510341,0.000005422487,0.00002233145,0.0004650263,0.00001598946,0.0001492262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01190986,"threshold_uncertainty_score":0.04616421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1522296097842501,"score_gpt":0.5066089450856105,"score_spread":0.3543793353013603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}