{"id":"W4383532359","doi":"10.1101/2023.07.06.548016","title":"A Novel Drosophila Model to Investigate Adipose Tissue Macrophage Infiltration (ATM) and Obesity highlights the Therapeutic Potential of Attenuating Eiger/TNFα Signaling to Ameliorate Insulin Resistance and ATM","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Scheme for Promotion of Academic and Research Collaboration; University of Toronto","keywords":"Adipose tissue; Insulin resistance; Adipocyte; Immune system; Infiltration (HVAC); Inflammation; Biology; Insulin; Cancer research; Endocrinology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308509,0.0006801361,0.0002513962,0.0007168257,0.0003115052,0.0002909995,0.0003318274,0.0005695348,0.002372479],"category_scores_gemma":[0.00007232872,0.0002132116,0.0004788876,0.0001670281,0.0003927321,0.000353773,0.0004455218,0.001020754,0.0003528626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004156035,"about_ca_system_score_gemma":0.0002892146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008184739,"about_ca_topic_score_gemma":0.001871957,"domain_scores_codex":[0.9998629,0.00001744101,0.00001784325,0.00005118403,0.00002934622,0.00002124219],"domain_scores_gemma":[0.9998571,0.00001801948,0.00005556837,0.00001418913,0.0000104847,0.00004470997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001041461,0.00005224035,0.0004475288,0.00005192296,0.000007554296,0.0001192499,0.00002758599,0.00008295216,0.9971107,0.0004234443,0.00006587118,0.001506766],"study_design_scores_gemma":[0.0001298733,0.001349015,0.0141794,0.00006905904,0.0001086733,0.001537831,0.0002029179,0.003825664,0.9664924,0.0004506932,0.01161805,0.00003649861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707987,0.001417989,0.02044831,0.0004114794,0.00009595616,0.0002427398,0.002539896,0.0003260952,0.003718778],"genre_scores_gemma":[0.9391747,0.001740725,0.04314477,0.0002802398,0.00002246737,0.0005441425,0.001867667,0.0001312794,0.01309393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002372479,"threshold_uncertainty_score":0.007936716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04357491020988739,"score_gpt":0.2679625486629151,"score_spread":0.2243876384530277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}