{"id":"W4383532426","doi":"10.1101/2023.07.07.548075","title":"Non-decameric NLRP3 forms an MTOC-independent inflammasome","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"Universitetet i Oslo; Eberhard Karls Universität Tübingen; Uppsala Universitet; Deutsche Forschungsgemeinschaft","keywords":"Inflammasome; Chemistry; Cell biology; ADP ribosylation factor; Microtubule; Biophysics; Golgi apparatus; Biology; Receptor; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001760587,0.0002111579,0.0001709135,0.0001222654,0.0001787523,0.0003553499,0.0001267554,0.0002710073,0.001843873],"category_scores_gemma":[0.0001642865,0.0001059785,0.0002759534,0.0001085755,0.0002801191,0.0002646488,0.0002776524,0.0005732087,0.0007536807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002984219,"about_ca_system_score_gemma":0.0002002623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002503151,"about_ca_topic_score_gemma":0.0003246837,"domain_scores_codex":[0.9998858,0.00001479737,0.00001124829,0.00003553928,0.00002808511,0.00002449652],"domain_scores_gemma":[0.9998875,0.00001962525,0.00002738905,0.00002159481,0.00001589262,0.00002798414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001426639,0.0000114096,0.0003777666,0.0000419192,0.000004667858,0.000124266,0.0000209954,0.00006790758,0.9979381,0.0005086103,0.0001202484,0.000641502],"study_design_scores_gemma":[0.00004657275,0.00007376181,0.009387296,0.00001211246,0.000009606742,0.00116164,0.00007047306,0.002304914,0.980995,0.0008868168,0.00504278,0.000009050453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860401,0.0009806743,0.008688185,0.0004215001,0.00008392949,0.00002930638,0.0005595665,0.000115333,0.003081476],"genre_scores_gemma":[0.9910269,0.0003455762,0.004686154,0.0001099898,0.00001977656,0.00002824491,0.0006719005,0.00003975997,0.003071608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001843873,"threshold_uncertainty_score":0.006168365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106333124286086,"score_gpt":0.2265916338571419,"score_spread":0.2159583214285333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}