{"id":"W4383532426","doi":"10.1101/2023.07.07.548075","title":"Non-decameric NLRP3 forms an MTOC-independent inflammasome","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"Universitetet i Oslo; Eberhard Karls Universität Tübingen; Uppsala Universitet; Deutsche Forschungsgemeinschaft","keywords":"Inflammasome; Chemistry; Cell biology; ADP ribosylation factor; Microtubule; Biophysics; Golgi apparatus; Biology; Receptor; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000639241,0.0008673127,0.0006492339,0.0003177758,0.0002445762,0.0002595373,0.001208756,0.001145937,0.00003916183],"category_scores_gemma":[0.0001357209,0.0009258739,0.0003765821,0.0003977941,0.0001729661,0.00003286153,0.001302646,0.0008125503,0.0003506804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000112813,"about_ca_system_score_gemma":0.0007711108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008293686,"about_ca_topic_score_gemma":0.00002283324,"domain_scores_codex":[0.9960674,0.00009459284,0.0007561189,0.001583833,0.00048319,0.001014846],"domain_scores_gemma":[0.9961966,0.00001207902,0.0004903082,0.002518239,0.0004415381,0.0003412949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009095749,0.0001381272,0.008403065,0.0002101212,0.0003107156,0.00005150824,0.00001416664,0.0002652158,0.9896557,0.00008432599,0.0007672558,0.000008872928],"study_design_scores_gemma":[0.001278065,0.0004493016,0.1404907,0.0001813526,0.0001445483,5.968641e-8,0.00003143526,0.0002498396,0.8319905,0.00001024524,0.02322917,0.00194472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952354,0.0007827153,0.0008301959,0.0001209673,0.001568342,0.0009739599,0.0001547257,0.0002818254,0.000051876],"genre_scores_gemma":[0.9961649,0.001009065,0.0006906574,0.0002885801,0.000905516,0.0004844294,0.00001756471,0.000342428,0.00009687954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1576651,"threshold_uncertainty_score":0.9993192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106333124286086,"score_gpt":0.2265916338571419,"score_spread":0.2159583214285333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}