{"id":"W4383534456","doi":"10.3389/fnins.2023.1219299","title":"Implication of tau propagation on neurodegeneration in Alzheimer’s disease","year":2023,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Neurodegeneration; Neuroscience; Tau pathology; Tau protein; Disease; Tauopathy; Alzheimer's disease; Psychology; Biology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002438763,0.0002612929,0.0007452024,0.0009423537,0.0000476299,0.00002264906,0.0002357944,0.0000911561,0.000001951644],"category_scores_gemma":[0.0003564467,0.0002152753,0.0001650125,0.001693193,0.0001550712,0.0001395078,0.00005974106,0.0002846477,0.00002123111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001706754,"about_ca_system_score_gemma":0.0008390726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001554902,"about_ca_topic_score_gemma":0.00000261993,"domain_scores_codex":[0.9975436,0.0002091583,0.0005613942,0.0007301539,0.0006105251,0.0003451875],"domain_scores_gemma":[0.9988872,0.00004801327,0.0002429715,0.0005223692,0.00004898593,0.0002504977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0003166061,0.001645024,0.009370803,0.007445317,0.0002505961,0.0006657172,0.00004240511,0.0001163049,0.00002409758,0.0003190544,0.002814003,0.97699],"study_design_scores_gemma":[0.01356151,0.00744595,0.436922,0.119739,0.01655386,0.0001468189,0.0001200735,0.04014483,0.0008648159,0.002772037,0.3565927,0.005136523],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004438139,0.9957767,0.00008255672,0.0001049423,0.0005439115,0.002830582,0.00009354967,0.00004384257,0.00008014226],"genre_scores_gemma":[0.005404043,0.9936052,0.0001020577,0.00004934394,0.00004791246,0.0004967235,0.0002161393,0.00004595843,0.00003261893],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9718536,"threshold_uncertainty_score":0.8778672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1089231669330507,"score_gpt":0.3900548868982583,"score_spread":0.2811317199652076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}