{"id":"W4383535022","doi":"10.1038/s41467-023-39616-w","title":"Expanded vacuum-stable gels for multiplexed high-resolution spatial histopathology","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Stanford Maternal and Child Health Research Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; U.S. Food and Drug Administration; National Institute on Aging; Parker Institute for Cancer Immunotherapy; U.S. Department of Health and Human Services; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; Brigham and Women's Hospital; Gilead Sciences; Hamilton Health Sciences Foundation; Bill and Melinda Gates Foundation; Doris Duke Charitable Foundation","keywords":"Mass cytometry; High resolution; Computer science; Self-healing hydrogels; Image resolution; Nanotechnology; Biomedical engineering; Materials science; Biology; Artificial intelligence; Medicine; Geology; Remote sensing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002188757,0.0001330371,0.0001454264,0.0000766091,0.0003475278,0.00001894179,0.0006485083,0.0004666388,0.000006916477],"category_scores_gemma":[0.0001856649,0.000138547,0.0001089343,0.0001620402,0.0001129664,0.000005016577,0.0001859208,0.0002966942,0.00001686786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003148301,"about_ca_system_score_gemma":0.00006721709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009970963,"about_ca_topic_score_gemma":0.001213318,"domain_scores_codex":[0.9991015,0.0000950508,0.0002072218,0.0002622585,0.00007973322,0.0002542747],"domain_scores_gemma":[0.9984692,0.00008354514,0.00007275237,0.001153289,0.000167411,0.00005376215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009492173,0.0001083148,0.001111518,0.00001165699,0.00002269905,5.045957e-7,0.00007512452,0.00007911259,0.9818769,0.001890794,0.01299553,0.001732899],"study_design_scores_gemma":[0.002578329,0.0003198902,0.02072928,0.00001982155,0.00007912659,0.00001207485,0.00009011453,0.006309834,0.1576445,0.001029529,0.8106703,0.0005172637],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465467,0.007741054,0.03145907,0.007193921,0.002531139,0.001699866,0.001002775,0.0004060108,0.001419458],"genre_scores_gemma":[0.9842753,0.0006425239,0.009752191,0.0003749929,0.0002032587,0.0001871836,0.003473351,0.00003133447,0.00105987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8242325,"threshold_uncertainty_score":0.5649784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02830003561195854,"score_gpt":0.2920674733071955,"score_spread":0.2637674376952369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}