{"id":"W4383535022","doi":"10.1038/s41467-023-39616-w","title":"Expanded vacuum-stable gels for multiplexed high-resolution spatial histopathology","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Stanford Maternal and Child Health Research Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; U.S. Food and Drug Administration; National Institute on Aging; Parker Institute for Cancer Immunotherapy; U.S. Department of Health and Human Services; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; Brigham and Women's Hospital; Gilead Sciences; Hamilton Health Sciences Foundation; Bill and Melinda Gates Foundation; Doris Duke Charitable Foundation","keywords":"Mass cytometry; High resolution; Computer science; Self-healing hydrogels; Image resolution; Nanotechnology; Biomedical engineering; Materials science; Biology; Artificial intelligence; Medicine; Geology; Remote sensing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004028491,0.0005429317,0.0001847294,0.0004871759,0.0001891914,0.0004352352,0.0002903775,0.0003845512,0.002519852],"category_scores_gemma":[0.0003243202,0.0002915179,0.0001673233,0.0001718084,0.000287966,0.0004181707,0.0004515338,0.0005613139,0.0006939674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554111,"about_ca_system_score_gemma":0.0001900179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001693221,"about_ca_topic_score_gemma":0.0007550871,"domain_scores_codex":[0.9997769,0.00003244593,0.00001393705,0.00006637527,0.00007934299,0.00003100613],"domain_scores_gemma":[0.9997553,0.00007207445,0.00007605039,0.00003736549,0.00003010846,0.00002901944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002130722,0.00001043915,0.00009564498,0.00003290447,0.000003452543,0.0000335676,0.00001756628,0.00009679771,0.9962974,0.0002482825,0.0001096033,0.003033083],"study_design_scores_gemma":[0.000006629288,0.00005488312,0.001002896,0.00001080593,0.000007819297,0.0002175355,0.00001865912,0.001562589,0.9920685,0.0001904523,0.004848401,0.00001089691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6107458,0.005200783,0.3669023,0.0007270683,0.0002638953,0.0006039035,0.0024714,0.002367672,0.0107172],"genre_scores_gemma":[0.7058106,0.00343022,0.2764315,0.000408261,0.0001202773,0.001080051,0.001617601,0.0003662976,0.01073508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002519852,"threshold_uncertainty_score":0.008429706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02830003561195854,"score_gpt":0.2920674733071955,"score_spread":0.2637674376952369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}