{"id":"W4383553191","doi":"10.3390/curroncol30070474","title":"Antibody–Drug Conjugates in Breast Cancer: Ascent to Destiny and Beyond—A 2023 Review","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Medicine; Trastuzumab emtansine; Breast cancer; Trastuzumab; Cancer; Antibody-drug conjugate; Metastatic breast cancer; Clinical trial; Drug; Oncology; Internal medicine; Pharmacology; Immunology; Antibody; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001740289,0.0005946644,0.004149833,0.0006667593,0.00006039106,0.00002463921,0.0004259975,0.0003131294,0.0006876103],"category_scores_gemma":[0.0005978941,0.0004787251,0.0003091329,0.001710714,0.0002178912,0.00003761437,0.0005605588,0.001695412,0.001097438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001905155,"about_ca_system_score_gemma":0.003915975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003145345,"about_ca_topic_score_gemma":0.0004109616,"domain_scores_codex":[0.9954534,0.0006817324,0.00129899,0.00105665,0.0005663173,0.0009429695],"domain_scores_gemma":[0.9973944,0.0007070129,0.0003238808,0.0006194227,0.0002715898,0.0006836903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001832031,0.0001606542,0.0008671508,0.1872756,0.00008023858,0.0002377656,0.00003992899,6.758573e-8,6.953317e-7,0.00001664228,0.07680069,0.7345023],"study_design_scores_gemma":[0.000432677,0.0001511441,0.0002832814,0.2402683,0.0006555621,0.0003963022,0.00001448437,0.000003275111,1.400237e-7,0.00001098156,0.7574943,0.0002895763],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001756788,0.9848779,0.000001631554,0.007224094,0.002012764,0.004549234,0.0005263674,0.00008307886,0.0007073279],"genre_scores_gemma":[8.721764e-7,0.9953166,0.00004724589,0.0007007708,0.0008455879,0.001819174,0.0005159352,0.0001221185,0.0006316928],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7342127,"threshold_uncertainty_score":0.9997665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2938468114277656,"score_gpt":0.5896260345667751,"score_spread":0.2957792231390095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}