{"id":"W4383556694","doi":"10.1158/2767-9764.crc-23-0111","title":"Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy","year":2023,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Genentech; Astellas Pharma; Academy of Medical Sciences; China Scholarship Council; National Institute for Health and Care Research; Wilhelm Sander-Stiftung; Medical Research Council; Sanofi; Prostate Cancer UK; Prostate Cancer Foundation","keywords":"Fulvestrant; Estrogen receptor; Cancer research; Breast cancer; Estrogen receptor alpha; Androgen receptor; Imidazopyridine; Prostate cancer; Cancer; Pharmacology; Transactivation; Estrogen; Cell growth; Chemistry; Internal medicine; Biology; Medicine; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008633248,0.0001237705,0.0001412607,0.0001559008,0.0005267352,0.00004821082,0.0009009717,0.000158718,0.00002358477],"category_scores_gemma":[0.00008235297,0.000117131,0.00008616338,0.0006366275,0.0003852355,0.00002022911,0.0001199414,0.0002450071,0.00001094085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000895053,"about_ca_system_score_gemma":0.0007228664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007097659,"about_ca_topic_score_gemma":0.0003541977,"domain_scores_codex":[0.9983711,0.0005366341,0.000231007,0.0002866921,0.0002401102,0.0003344179],"domain_scores_gemma":[0.997483,0.0001238116,0.0001001184,0.001255352,0.0008936165,0.000144082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004678864,0.0002761008,0.001158618,0.00002273724,0.0001484436,1.836012e-7,0.0001991862,0.00041803,0.9831578,0.0004081934,0.002105449,0.01163738],"study_design_scores_gemma":[0.001337164,0.0006719674,0.004038956,0.00004113548,0.0000255166,0.000003890248,0.0004206968,0.006688591,0.9778226,0.000346902,0.008387281,0.0002152741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929611,0.003072723,0.00007071804,0.002204138,0.00006135907,0.0009398617,0.0005861464,0.00003986268,0.00006408415],"genre_scores_gemma":[0.9901177,0.006291219,0.0003030606,0.00004630932,0.00009866553,0.00169511,0.001233672,0.00004409876,0.0001701746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0114221,"threshold_uncertainty_score":0.4776465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08932779712755888,"score_gpt":0.4534492911967902,"score_spread":0.3641214940692313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}