{"id":"W4383556694","doi":"10.1158/2767-9764.crc-23-0111","title":"Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy","year":2023,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Genentech; Astellas Pharma; Academy of Medical Sciences; China Scholarship Council; National Institute for Health and Care Research; Wilhelm Sander-Stiftung; Medical Research Council; Sanofi; Prostate Cancer UK; Prostate Cancer Foundation","keywords":"Fulvestrant; Estrogen receptor; Cancer research; Breast cancer; Estrogen receptor alpha; Androgen receptor; Imidazopyridine; Prostate cancer; Cancer; Pharmacology; Transactivation; Estrogen; Cell growth; Chemistry; Internal medicine; Biology; Medicine; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009289331,0.0004173472,0.000316199,0.0002364803,0.000091362,0.0002213379,0.0002906905,0.0002647374,0.001388702],"category_scores_gemma":[0.00008181456,0.000125487,0.0002577601,0.0001475226,0.0001199561,0.0001408517,0.0001480196,0.0004364869,0.0004498569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00029766,"about_ca_system_score_gemma":0.0001890361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004526549,"about_ca_topic_score_gemma":0.0008690919,"domain_scores_codex":[0.999952,0.000006227031,0.000003133705,0.00001146312,0.00001353863,0.0000136122],"domain_scores_gemma":[0.9999669,0.000004026927,0.0000106219,0.000002810058,0.000006633185,0.000009070752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000253531,0.000206236,0.0001887424,0.0002791137,0.00002365445,0.0002561711,0.00003343471,0.000779846,0.9706078,0.0006171567,0.0004449891,0.02630935],"study_design_scores_gemma":[0.0007005675,0.01063404,0.00459775,0.00006058672,0.0001446729,0.001513312,0.00003327442,0.003599592,0.9440713,0.0002427181,0.03436128,0.00004075793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9463648,0.0232483,0.01453365,0.0004979207,0.0001854338,0.0006365895,0.0009703609,0.0004434532,0.01311947],"genre_scores_gemma":[0.9721717,0.0102301,0.009578409,0.0001932317,0.00003849178,0.0001772203,0.0007337667,0.00002081935,0.006856242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001388702,"threshold_uncertainty_score":0.004645646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08932779712755888,"score_gpt":0.4534492911967902,"score_spread":0.3641214940692313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}