{"id":"W4383602928","doi":"10.1038/s41531-023-00555-4","title":"Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease","year":2023,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Instituto de Salud Carlos III; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Fleni; IXICO; Deutsches Zentrum für Neurodegenerative Erkrankungen; H. Lundbeck A/S; Servier; Eisai; Korea Health Industry Development Institute; Northern California Institute for Research and Education; Japan Agency for Medical Research and Development; Fondation Brain Canada; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Hope Center for Neurological Disorders; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Michael J. Fox Foundation for Parkinson's Research; Foundation for the National Institutes of Health","keywords":"LRRK2; Proteome; Proteomics; Biology; Computational biology; Single-nucleotide polymorphism; Locus (genetics); Mendelian randomization; Disease; Genetics; Parkinson's disease; Bioinformatics; Medicine; Gene; Genotype; Pathology; Genetic variants","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006259189,0.0003585915,0.0004114863,0.001032446,0.0002628629,0.0005716646,0.0001658991,0.0002992081,0.001212421],"category_scores_gemma":[0.0008562293,0.0001311971,0.0005547456,0.001400119,0.0002088204,0.000137672,0.0003920408,0.0002880018,0.0001733596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001940693,"about_ca_system_score_gemma":0.0001422768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001301691,"about_ca_topic_score_gemma":0.002536097,"domain_scores_codex":[0.9995432,0.00009002809,0.00005334547,0.0001855641,0.00008105082,0.00004688992],"domain_scores_gemma":[0.9994799,0.0001439998,0.0002221464,0.00006062486,0.00004690735,0.00004643728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001631495,0.00006223466,0.9133808,0.0001025558,0.001711984,0.001100608,0.0001550028,0.001030115,0.06707904,0.0001724747,0.0006454921,0.01292819],"study_design_scores_gemma":[0.00002511238,0.00007390293,0.9955679,0.000006333559,0.000236163,0.00058646,0.00004974789,0.0006635507,0.002152638,0.0001294769,0.0005021725,0.000006522591],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981753,0.0004555556,0.0003431581,0.00003531648,0.000003587833,0.00000313402,0.0007469151,0.00001358001,0.0002234385],"genre_scores_gemma":[0.9985734,0.0001516886,0.0003247043,0.00002501321,0.000005452677,0.000003618592,0.0007918077,0.000004637545,0.0001196433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301691,"threshold_uncertainty_score":0.004055917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04563218305365124,"score_gpt":0.3288414499894029,"score_spread":0.2832092669357517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}