{"id":"W4383645880","doi":"10.1101/2023.07.06.23292311","title":"Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies <i>LRRC4C, LHX5-AS1</i> and nominates ancestry-specific loci <i>PTPRK</i> , <i>GRB14</i> , and <i>KIAA0825</i> as novel risk loci for Alzheimer’s disease: the Alzheimer’s Disease Genetics Consortium","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; National Institutes of Health; H. Lundbeck A/S; Genentech; IXICO; Universitat de Barcelona; Meso Scale Diagnostics; Medical Research Council; Hersenstichting; Bristol-Myers Squibb; North Bristol NHS Trust; Eisai; Bundesministerium für Bildung und Forschung; University of Pennsylvania; Newcastle University; Biogen; BioClinica; U.S. Department of Defense; Eli Lilly and Company; Alzheimer's Research Trust; F. Hoffmann-La Roche; Universität des Saarlandes; Stichting MS Research; Alzheimer's Association","keywords":"Biology; Genome; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006741387,0.001472738,0.002599694,0.002042652,0.00100548,0.001982721,0.001216094,0.001129018,0.002663],"category_scores_gemma":[0.008294798,0.0007317216,0.01333503,0.003886278,0.0004099766,0.0005430857,0.001297387,0.001445098,0.0002546583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005975916,"about_ca_system_score_gemma":0.0007440442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01047843,"about_ca_topic_score_gemma":0.01617186,"domain_scores_codex":[0.9958352,0.00179932,0.0004673632,0.001230142,0.0003694393,0.0002985276],"domain_scores_gemma":[0.9955199,0.002334751,0.000545149,0.0009960349,0.0004075516,0.0001965672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00690345,0.00006805901,0.521854,0.002553,0.4434405,0.0006012086,0.0001681605,0.00232414,0.004075924,0.0004715339,0.002546575,0.01499349],"study_design_scores_gemma":[0.001391772,0.0005011614,0.3901007,0.0005651624,0.5931735,0.0006584527,0.0002246925,0.005480083,0.002053503,0.000987244,0.004809392,0.0000542643],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8459201,0.124741,0.01513765,0.001477499,0.0005536017,0.0001827161,0.008943566,0.0004218884,0.002621875],"genre_scores_gemma":[0.9917732,0.004086161,0.001727736,0.0002083197,0.0000893153,0.00007547299,0.001590445,0.00004522707,0.0004041676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01047843,"threshold_uncertainty_score":0.03565228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1328140658070583,"score_gpt":0.3391501713299888,"score_spread":0.2063361055229304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}