{"id":"W4383683835","doi":"10.58931/cibdt.2023.115","title":"JAK inhibitors for the treatment of inflammatory bowel disease","year":2023,"lang":"en","type":"article","venue":"Canadian IBD Today","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Tofacitinib; Janus kinase; Medicine; Inflammatory bowel disease; Immunology; Ulcerative colitis; Immunosuppression; Psoriasis; Rheumatoid arthritis; STAT protein; JAK-STAT signaling pathway; Tyrosine kinase; Pharmacology; Disease; Signal transduction; STAT3; Internal medicine; Cytokine; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035358,0.0006193533,0.0005197535,0.0006207523,0.0003046002,0.0008709208,0.0005407798,0.001030652,0.04419404],"category_scores_gemma":[0.0003877826,0.0001092551,0.0004539211,0.0003884457,0.0002546053,0.0005791616,0.0006942694,0.002338932,0.02253214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004750396,"about_ca_system_score_gemma":0.0004354714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004465705,"about_ca_topic_score_gemma":0.00206807,"domain_scores_codex":[0.9997619,0.00004167945,0.00001872294,0.00003394754,0.0001031543,0.0000405295],"domain_scores_gemma":[0.9998432,0.00002652313,0.0000297172,0.000006164023,0.00004743132,0.00004693013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003223107,0.0001351137,0.0001979814,0.00145432,0.00004675915,0.0002947809,0.00003110521,0.0001708103,0.005550524,0.007682387,0.3445518,0.6395622],"study_design_scores_gemma":[0.0001270316,0.0001626475,0.0004121043,0.0003516354,0.00001561872,0.0004858722,0.000006705471,0.00006478017,0.0004204914,0.0009326496,0.9970123,0.00000827708],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.003245667,0.7929407,0.001923103,0.02381827,0.01105082,0.0002173427,0.001310817,0.0005806471,0.1649127],"genre_scores_gemma":[0.02926401,0.6989354,0.005428285,0.02778939,0.008556865,0.0002712973,0.003289227,0.0001346896,0.2263308],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04419404,"threshold_uncertainty_score":0.1478438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008778784336343465,"score_gpt":0.2269513760202839,"score_spread":0.2181725916839404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}