{"id":"W4383683835","doi":"10.58931/cibdt.2023.115","title":"JAK inhibitors for the treatment of inflammatory bowel disease","year":2023,"lang":"en","type":"article","venue":"Canadian IBD Today","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Tofacitinib; Janus kinase; Medicine; Inflammatory bowel disease; Immunology; Ulcerative colitis; Immunosuppression; Psoriasis; Rheumatoid arthritis; STAT protein; JAK-STAT signaling pathway; Tyrosine kinase; Pharmacology; Disease; Signal transduction; STAT3; Internal medicine; Cytokine; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009457291,0.0001367768,0.00007858178,0.00008461802,0.0001493698,0.00001492866,0.0001615816,0.00007537835,0.00003080172],"category_scores_gemma":[0.0000799855,0.000109101,0.0001663006,0.00007430083,0.0001010114,0.000002783079,0.0000154977,0.00002167995,0.00004380406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000787766,"about_ca_system_score_gemma":0.0008137277,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112313,"about_ca_topic_score_gemma":0.02999134,"domain_scores_codex":[0.9991819,0.00002663489,0.0001633371,0.00021795,0.00008018687,0.0003299827],"domain_scores_gemma":[0.9989375,0.00002501372,0.00004741365,0.0004600963,0.00006650944,0.0004635019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001707313,0.00030849,0.3981976,0.0006004991,0.001241421,0.001311054,0.002058594,0.004826896,0.04093586,0.005336534,0.5064898,0.03698593],"study_design_scores_gemma":[0.0007545684,0.0001170328,0.3470718,0.00001292012,0.00007010553,8.151962e-7,0.0001304787,0.0003064013,0.005436652,0.0001249123,0.6457586,0.00021571],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967363,0.0005848412,0.00001187432,0.0006774683,0.0004118859,0.0006675671,0.0005137951,0.00001907057,0.0003771225],"genre_scores_gemma":[0.995782,0.0001779048,0.0000122181,0.0002402373,0.0004416508,0.00028637,0.0002717161,0.00003433324,0.002753598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1392688,"threshold_uncertainty_score":0.9877088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008778784336343465,"score_gpt":0.2269513760202839,"score_spread":0.2181725916839404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}