{"id":"W4383684021","doi":"10.58931/cect.2023.2122","title":"Genetics of retinal degeneration in 2023","year":2023,"lang":"en","type":"article","venue":"Canadian Eye Care Today","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"RPE65; Genetic testing; Retinal degeneration; Disease; Retinal; Medicine; Bioinformatics; Genetics; Biology; Gene; Pathology; Genetic enhancement; Ophthalmology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007276232,0.00007240581,0.00006953008,0.0001329613,0.00002934739,0.000006875439,0.00009679553,0.00009472409,0.00003393785],"category_scores_gemma":[0.00004514926,0.00008157908,0.00003091905,0.0002254639,0.00002944925,0.000001320031,0.00002012119,0.00003582628,0.00002942694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003486398,"about_ca_system_score_gemma":0.0003527006,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002666287,"about_ca_topic_score_gemma":0.129284,"domain_scores_codex":[0.9994205,0.00002164548,0.0001263185,0.0001590145,0.00006733632,0.0002052258],"domain_scores_gemma":[0.9996681,0.000002785121,0.00002329507,0.0001338589,0.00006968259,0.0001023107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003734037,0.000008386287,0.710484,0.00008515374,0.00001942987,0.0000458052,0.0008461396,0.0009887143,0.2323894,0.0002057612,0.03973578,0.0151541],"study_design_scores_gemma":[0.0007441887,0.0001770393,0.6205354,0.00004843738,0.00001220259,0.000002494793,0.002441318,0.0001254752,0.1997106,0.0001131945,0.1755918,0.0004979004],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908653,0.0009701466,0.000009960695,0.0001910966,0.0001345598,0.00009271904,0.00002863053,0.000004671116,0.00770292],"genre_scores_gemma":[0.9974812,0.0002189518,0.0001154413,0.0001243159,0.00005408458,0.0000110532,0.0006269505,0.00001113329,0.001356859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.135856,"threshold_uncertainty_score":0.8866042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007617526973127096,"score_gpt":0.2376311859108728,"score_spread":0.2300136589377458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}