{"id":"W4383710651","doi":"10.15252/embr.202256150","title":"RNA polymerase II CTD is dispensable for transcription and required for termination in human cells","year":2023,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"College of Natural Resources and Sciences, Humboldt State University; Institut National Du Cancer; CNIB; Centre National de la Recherche Scientifique; Bundesministerium für Bildung und Forschung; Agence Nationale de la Recherche","keywords":"CTD; RNA polymerase II; Transcription (linguistics); Biology; Cell biology; Mutant; Molecular biology; Gene; Genetics; Gene expression; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955993,0.00008449231,0.00009930987,0.00004398109,0.0001104747,0.00001885029,0.00003345797,0.00009133379,0.00000477103],"category_scores_gemma":[0.00001623406,0.00009097441,0.00005546591,0.00004654421,0.00001850072,0.000004307306,0.00002475936,0.00001978057,3.23919e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001148431,"about_ca_system_score_gemma":0.0000209996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001904519,"about_ca_topic_score_gemma":0.00005823055,"domain_scores_codex":[0.9992883,0.000006518647,0.0002351662,0.0002657952,0.00004553198,0.0001586941],"domain_scores_gemma":[0.9996673,0.000004776761,0.00009427939,0.0001700293,0.00003067892,0.00003291399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001437549,0.00002582881,0.0002222218,0.00005503779,0.000008347344,0.000006706251,0.0001434218,0.0000275983,0.9957089,0.00004141427,0.002385049,0.001361107],"study_design_scores_gemma":[0.0006445196,0.0002744508,0.002404437,0.00001811407,0.000023062,0.00002128734,0.00007947945,0.002933802,0.9818037,0.002325954,0.009280374,0.0001907915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983553,0.00007791637,0.0005662562,0.0001802037,0.0001569435,0.0004236834,0.00004119125,0.00001038026,0.0001881007],"genre_scores_gemma":[0.9948601,0.00004496345,0.0004161832,0.00007144787,0.00007429525,0.00009558421,0.0005686854,0.00001968786,0.003849054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01390516,"threshold_uncertainty_score":0.3709829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207656518939135,"score_gpt":0.2630228260959643,"score_spread":0.2509462609065729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}