{"id":"W4383711045","doi":"10.1111/jcmm.17839","title":"Calreticulin: Endoplasmic reticulum Ca<sup>2+</sup> gatekeeper","year":2023,"lang":"en","type":"review","venue":"Journal of Cellular and Molecular Medicine","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University Hospital Foundation; Canada Foundation for Innovation; Multiple Sclerosis Society; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Calreticulin; Endoplasmic reticulum; Chaperone (clinical); Cell biology; Calcium-binding protein; Unfolded protein response; STIM1; Calcium signaling; Biology; Lumen (anatomy); Cellular compartment; Chemistry; Calcium; Signal transduction; Biochemistry; Medicine; Cell; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003152033,0.001091968,0.001070046,0.002001826,0.0003099281,0.00107113,0.0009206306,0.001137621,0.004237986],"category_scores_gemma":[0.0003449152,0.0002185098,0.0003344702,0.002315676,0.0005031329,0.001331804,0.0008140834,0.002003469,0.004866817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007800712,"about_ca_system_score_gemma":0.0008740907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007873,"about_ca_topic_score_gemma":0.001032993,"domain_scores_codex":[0.9998654,0.00001747556,0.00001967074,0.00002828235,0.00005283678,0.00001638431],"domain_scores_gemma":[0.999863,0.00003438675,0.00002444346,0.00000531564,0.000049789,0.00002305154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001266298,0.00006295042,0.0001459425,0.0111591,0.00005723208,0.0003005403,0.00004800113,0.0003300387,0.004767408,0.006251722,0.05647985,0.9202707],"study_design_scores_gemma":[0.00001222029,0.00004027386,0.0003806794,0.0008570859,0.00002981094,0.000776377,0.00002253392,0.00005983084,0.0006954523,0.001291295,0.9958243,0.00001008048],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001842902,0.995826,0.0002663743,0.0003889654,0.0006727398,0.000007871716,0.00004793748,0.00002364678,0.002582194],"genre_scores_gemma":[0.00178896,0.9931036,0.0004430035,0.0004960119,0.0003242446,0.00001613411,0.0001269223,0.000005862632,0.003695382],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004237986,"threshold_uncertainty_score":0.01417744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01730062987975486,"score_gpt":0.2914752432166623,"score_spread":0.2741746133369075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}