{"id":"W4383746190","doi":"10.1038/s41592-023-01913-z","title":"A positively tuned voltage indicator for extended electrical recordings in the brain","year":2023,"lang":"en","type":"article","venue":"Nature Methods","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Stanford Maternal and Child Health Research Institute; National Institute of Neurological Disorders and Stroke; National Eye Institute; Wu Tsai Neurosciences Institute, Stanford University; Stanford Bio-X; Vallee Foundation; Epilepsy Society; Office of Naval Research; Chinese Academy of Sciences; National Institute of Mental Health; Human Frontier Science Program; Parkinson's Foundation; National Defense Science and Engineering Graduate; Simons Foundation; American Epilepsy Society; U.S. Department of Health and Human Services; National Institutes of Health; James S. McDonnell Foundation; U.S. Department of Defense","keywords":"Subthreshold conduction; Voltage; Voltage-sensitive dye; Microscopy; Fluorescence; Calcium imaging; Temporal resolution; Optical recording; Two-photon excitation microscopy; Fluorescence-lifetime imaging microscopy; Materials science; Fluorescence microscope; Microscope; Electrophysiology; Calcium; Neuroscience; Biophysics; Optoelectronics; Optics; Physics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000617185,0.0004338115,0.0003145999,0.0003429239,0.000324885,0.0009300657,0.0009712253,0.00114962,0.002348499],"category_scores_gemma":[0.001435905,0.0002452025,0.0002068384,0.0003259683,0.0008160123,0.001149558,0.001336456,0.001253221,0.0009604247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003874651,"about_ca_system_score_gemma":0.0002774455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008576953,"about_ca_topic_score_gemma":0.0002714153,"domain_scores_codex":[0.9995118,0.00009893755,0.00002340119,0.0001720206,0.0001222827,0.00007164296],"domain_scores_gemma":[0.9993441,0.0002261172,0.0001371528,0.00006648582,0.00008718752,0.0001390075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007726912,0.00001439057,0.0001072348,0.00006432078,0.000004067056,0.00007144883,0.00002781829,0.0001159445,0.9912531,0.001783052,0.0002355853,0.006245774],"study_design_scores_gemma":[0.00003178434,0.0002453832,0.001372941,0.00004160597,0.00002778887,0.0004834156,0.00003809701,0.004898312,0.9838941,0.001516259,0.007425642,0.00002467999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3939818,0.002784277,0.5839635,0.001454688,0.0007745711,0.0001792675,0.0005216143,0.00160099,0.01473942],"genre_scores_gemma":[0.8394718,0.001482818,0.1512089,0.001037177,0.0002314524,0.0002313293,0.0003209029,0.000431703,0.005583987],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002348499,"threshold_uncertainty_score":0.007856548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04429161206435925,"score_gpt":0.4104770792509169,"score_spread":0.3661854671865576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}