{"id":"W4383746430","doi":"10.1016/s2468-1253(23)00148-6","title":"Efficacy and safety of the siRNA JNJ-73763989 and the capsid assembly modulator JNJ-56136379 (bersacapavir) with nucleos(t)ide analogues for the treatment of chronic hepatitis B virus infection (REEF-1): a multicentre, double-blind, active-controlled, randomised, phase 2b trial","year":2023,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"Janssen Research and Development; Gilead Sciences; GlaxoSmithKline; Eisai; Arrowhead Pharmaceuticals; Fujirebio US; Bristol-Myers Squibb","keywords":"Medicine; Hepatitis B virus; HBeAg; Hepatitis B; Internal medicine; Pegylated interferon; HBsAg; Gastroenterology; Virology; Chronic hepatitis; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001664084,0.001833507,0.002870379,0.0003831637,0.0003651607,0.001273053,0.0009647291,0.002253748,0.006728329],"category_scores_gemma":[0.001421559,0.0007093056,0.002307567,0.0004452946,0.001194595,0.001019227,0.0003502804,0.002761669,0.001219862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009446038,"about_ca_system_score_gemma":0.001193078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001685888,"about_ca_topic_score_gemma":0.003370608,"domain_scores_codex":[0.9993098,0.0003396591,0.0000495892,0.0001097763,0.0000702777,0.0001209516],"domain_scores_gemma":[0.9993533,0.0001764563,0.0001716967,0.00004597864,0.00005174533,0.0002008908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.969234,0.002965291,0.0003146343,0.001126536,0.001201682,0.00003172089,0.00003102558,0.0002294873,0.003827263,0.0001010153,0.000920373,0.02001704],"study_design_scores_gemma":[0.9407602,0.05561455,0.001586629,0.00005609761,0.0006442221,0.00003183241,0.00001693759,0.0001792749,0.0004153008,0.00009315048,0.0005835618,0.00001842128],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740854,0.01691411,0.0004486556,0.0007572381,0.0008572571,0.001887045,0.001419647,0.0001338878,0.003496747],"genre_scores_gemma":[0.9812403,0.007568161,0.001006816,0.001317399,0.0005308907,0.00177744,0.00157825,0.00003545827,0.004945107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006728329,"threshold_uncertainty_score":0.0225085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03314728667952843,"score_gpt":0.3103874546697508,"score_spread":0.2772401679902223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}