{"id":"W4383746430","doi":"10.1016/s2468-1253(23)00148-6","title":"Efficacy and safety of the siRNA JNJ-73763989 and the capsid assembly modulator JNJ-56136379 (bersacapavir) with nucleos(t)ide analogues for the treatment of chronic hepatitis B virus infection (REEF-1): a multicentre, double-blind, active-controlled, randomised, phase 2b trial","year":2023,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"Janssen Research and Development; Gilead Sciences; GlaxoSmithKline; Eisai; Arrowhead Pharmaceuticals; Fujirebio US; Bristol-Myers Squibb","keywords":"Medicine; Hepatitis B virus; HBeAg; Hepatitis B; Internal medicine; Pegylated interferon; HBsAg; Gastroenterology; Virology; Chronic hepatitis; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001021618,0.0005413329,0.00250241,0.0001831688,0.0006275813,0.00002281261,0.0003162691,0.0002261866,0.0000169873],"category_scores_gemma":[0.0002640284,0.0002418996,0.0004765721,0.0003074442,0.002350215,0.00008526541,0.0001548029,0.0003946588,0.000003671695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002161799,"about_ca_system_score_gemma":0.000164467,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.008271955,"about_ca_topic_score_gemma":0.1021728,"domain_scores_codex":[0.9959959,0.001102862,0.001063282,0.0006266129,0.0003215408,0.0008897543],"domain_scores_gemma":[0.994866,0.002957628,0.0009226094,0.0008982096,0.000239528,0.0001159816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.794534,0.0007889668,0.1942718,0.00008015778,0.004005007,0.0000190964,0.001588519,0.0001001461,0.0008541347,0.0001110941,0.0003055689,0.003341469],"study_design_scores_gemma":[0.8750246,0.009497297,0.09694602,0.00007825553,0.003509147,0.0001651883,0.0001040243,0.01222372,0.0006014738,0.00005414218,0.001648774,0.000147368],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812255,0.001274138,0.0005353284,0.005193971,0.0006429903,0.01081986,0.0002034265,0.00006723087,0.00003756633],"genre_scores_gemma":[0.9842007,0.01226723,0.00005135951,0.0006507637,0.0005478049,0.002138267,0.00004093174,0.00005488441,0.00004804091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09732582,"threshold_uncertainty_score":0.998332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03314728667952843,"score_gpt":0.3103874546697508,"score_spread":0.2772401679902223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}