{"id":"W4383817237","doi":"10.1016/j.humimm.2023.06.007","title":"The β2-adrenergic receptor agonist terbutaline upregulates T helper-17 cells in a protein kinase A-dependent manner","year":2023,"lang":"en","type":"article","venue":"Human Immunology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"RAR-related orphan receptor gamma; Rolipram; Terbutaline; CREB; CD28; Endocrinology; Peripheral blood mononuclear cell; Biology; Internal medicine; Chemistry; Molecular biology; T cell; Immunology; FOXP3; Phosphodiesterase; Medicine; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147882,0.0003402063,0.0002655236,0.0002677898,0.000223463,0.0004022432,0.0001341069,0.0002462406,0.003807779],"category_scores_gemma":[0.0001226075,0.0001796602,0.0003401272,0.0001557599,0.0001858403,0.0002041741,0.0001574439,0.00090351,0.0008725043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001662573,"about_ca_system_score_gemma":0.000177326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003137151,"about_ca_topic_score_gemma":0.0006538604,"domain_scores_codex":[0.9997255,0.00005519734,0.00001603187,0.00003134802,0.00006404756,0.0001078022],"domain_scores_gemma":[0.9998634,0.00004067274,0.00002891943,0.00001418481,0.0000135716,0.00003915505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005047875,0.0001010021,0.0001779265,0.00005032124,0.000009222164,0.0001129726,0.00001442865,0.00002705442,0.9968218,0.00004662301,0.00008747469,0.002046384],"study_design_scores_gemma":[0.0001598632,0.001263934,0.01682448,0.00002269629,0.00005575198,0.0003512733,0.0001730774,0.0004644614,0.9765388,0.0001287807,0.004006826,0.0000100311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860053,0.004370365,0.001363894,0.0003490418,0.0003905371,0.00006287923,0.0004385947,0.00007750795,0.006941695],"genre_scores_gemma":[0.9903842,0.002952391,0.0007778007,0.0001432348,0.0001406888,0.00006627156,0.0002941241,0.00001952275,0.005221708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003807779,"threshold_uncertainty_score":0.01273829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01575879585612154,"score_gpt":0.2352076637682899,"score_spread":0.2194488679121684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}