{"id":"W4383818514","doi":"10.3390/md21070396","title":"Brevetoxin versus Brevenal Modulation of Human Nav1 Channels","year":2023,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Australian Research Council; Alliance de recherche numérique du Canada; Russian Science Foundation; Victor Chang Cardiac Research Institute","keywords":"NAV1; Modulation (music); Chemistry; Nav1.5; Biophysics; Cell biology; Biology; Sodium channel; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195171,0.0002195482,0.0002307953,0.00006762255,0.0001052435,0.0002549824,0.0002788611,0.0002236971,0.0007973037],"category_scores_gemma":[0.0001960998,0.00007297532,0.0002562707,0.00008802448,0.0002014324,0.000213625,0.0001872646,0.0002421834,0.0001643396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002300878,"about_ca_system_score_gemma":0.0001375245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005318571,"about_ca_topic_score_gemma":0.0006026702,"domain_scores_codex":[0.9999026,0.00001849462,0.000005998596,0.00002035736,0.0000302818,0.00002233634],"domain_scores_gemma":[0.9999621,0.00001374878,0.00001129235,0.000003361695,0.000004507652,0.000004935169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002643503,0.0000371419,0.0006721491,0.00006374731,0.00001394006,0.0000763805,0.00002811426,0.005593935,0.9890521,0.0004591794,0.00003472461,0.003704217],"study_design_scores_gemma":[0.00004975968,0.0005427749,0.003591434,0.00001001349,0.0000325157,0.000186695,0.00005024747,0.03000649,0.9636706,0.0003135613,0.001532568,0.00001342029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954799,0.0006436246,0.003057526,0.00002593112,0.000006901799,0.000009838909,0.000051775,0.00003159119,0.000692862],"genre_scores_gemma":[0.9977107,0.0005399143,0.001223961,0.00002380048,0.000003110214,0.000009254858,0.00009166497,0.000008137047,0.0003894359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007973037,"threshold_uncertainty_score":0.002667248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01960810797913203,"score_gpt":0.2752941899366589,"score_spread":0.2556860819575268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}