{"id":"W4383818514","doi":"10.3390/md21070396","title":"Brevetoxin versus Brevenal Modulation of Human Nav1 Channels","year":2023,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Australian Research Council; Alliance de recherche numérique du Canada; Russian Science Foundation; Victor Chang Cardiac Research Institute","keywords":"NAV1; Modulation (music); Chemistry; Nav1.5; Biophysics; Cell biology; Biology; Sodium channel; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001518388,0.00008294569,0.00008697378,0.00007688601,0.00005692236,0.000007840164,0.00006868691,0.00008411133,0.000109495],"category_scores_gemma":[0.00003450773,0.0000858741,0.00006763611,0.0001829348,0.00002752862,0.000003543407,0.0001088478,0.00003734008,0.00003860696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009823464,"about_ca_system_score_gemma":0.00001457364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004213626,"about_ca_topic_score_gemma":0.00001069689,"domain_scores_codex":[0.9993897,0.00002742567,0.0001587455,0.0001743772,0.0001229909,0.0001267538],"domain_scores_gemma":[0.9996421,0.000007083061,0.00006565153,0.0001685247,0.00008154221,0.00003506552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005089261,0.00009869962,0.002373662,0.00006863107,0.0001036172,0.00000221183,0.0002992687,0.0076608,0.9258469,0.001154937,0.02496279,0.03691952],"study_design_scores_gemma":[0.009861433,0.001880486,0.1081185,0.00005090803,0.00006881241,0.00001256302,0.0008766873,0.03882434,0.7093263,0.002854983,0.127035,0.001090008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940777,0.000007545623,0.0003870485,0.0002039314,0.0008368718,0.00009870779,0.000006919421,0.00003332516,0.004347944],"genre_scores_gemma":[0.989628,0.00001538307,0.00003524865,0.00004316122,0.0005378859,0.00001046365,0.0008861698,0.00001441136,0.008829346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2165207,"threshold_uncertainty_score":0.3501844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01960810797913203,"score_gpt":0.2752941899366589,"score_spread":0.2556860819575268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}