{"id":"W4383872790","doi":"10.1001/jama.2023.8650","title":"DNA Sequencing in Adults With Acute Myeloid Leukemia to Detect Residual Disease Prior to Hematopoietic Cell Transplant","year":2023,"lang":"en","type":"letter","venue":"JAMA","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; NPM1; Myeloid leukemia; Minimal residual disease; Hematopoietic cell; Myeloid; Oncology; Hematopoietic stem cell transplantation; Disease; Leukemia; Internal medicine; Haematopoiesis; Immunology; Stem cell; Genetics; Gene; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001885944,0.0006678263,0.0008275298,0.0009898768,0.00115245,0.001123825,0.001687083,0.0117541,0.002234679],"category_scores_gemma":[0.01444332,0.0005959586,0.0005682308,0.0007675092,0.001118528,0.001356018,0.0003811215,0.01157438,0.001952908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001841305,"about_ca_system_score_gemma":0.001128476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003148883,"about_ca_topic_score_gemma":0.00444188,"domain_scores_codex":[0.9979926,0.0007088373,0.000363939,0.0002569566,0.0004825265,0.0001950586],"domain_scores_gemma":[0.9907657,0.005439213,0.0005597246,0.0002567408,0.001753152,0.001225463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.00038425,0.0001352592,0.02038322,0.0001882925,0.00009909097,0.02402828,0.0001953363,0.0002856841,0.001145057,0.001217255,0.9194559,0.0324824],"study_design_scores_gemma":[0.0009424178,0.001185086,0.06311452,0.002330751,0.0005178174,0.1108948,0.001816018,0.007555758,0.003973815,0.01278042,0.794646,0.0002425599],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.008176974,0.004319263,0.0005675344,0.9444892,0.03701922,0.00004673018,0.0002895729,0.0001071703,0.004984413],"genre_scores_gemma":[0.05061246,0.004350554,0.0007868543,0.8123496,0.1267701,0.00005373518,0.0002118046,0.00005848322,0.004806342],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0117541,"threshold_uncertainty_score":0.01335967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520594797562227,"score_gpt":0.2610556138613029,"score_spread":0.2458496658856807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}