{"id":"W4383872867","doi":"10.1128/mbio.00753-23","title":"Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts; Crohn's and Colitis Canada; Universities Space Research Association; Auris Health; Canadian Institute for Advanced Research; Michael Smith Health Research BC; National Science Foundation","keywords":"Gut flora; Strain (injury); Microbiology; Biology; Chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000309192,0.0000997623,0.00008061409,0.00004312321,0.00007341387,0.0000244049,0.0001385654,0.00009954014,0.00001349582],"category_scores_gemma":[0.00002673146,0.00008244806,0.00002871542,0.00008601753,0.00007094462,0.00000180047,0.0001132497,0.00007664338,0.00003594289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001780758,"about_ca_system_score_gemma":0.00002514297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000336289,"about_ca_topic_score_gemma":0.0001038045,"domain_scores_codex":[0.9991995,0.0001019375,0.000132892,0.0002656651,0.00005674213,0.0002433421],"domain_scores_gemma":[0.9996598,0.00001437315,0.00002264482,0.0002415261,0.00000375429,0.00005790286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004809305,0.00007926665,0.02664158,0.000007646697,0.000003343694,0.00001211067,0.0003139482,2.748836e-7,0.9684833,0.000003179654,0.00316993,0.001237297],"study_design_scores_gemma":[0.0003204556,0.0002494318,0.9066759,0.000008580601,0.000007691612,0.00003445718,0.0003151725,7.150855e-7,0.05150509,0.000007181955,0.04076339,0.0001119257],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980022,0.000152504,0.00000375984,0.001027334,0.00006143982,0.0003044147,0.0003614566,0.00001024513,0.00007663694],"genre_scores_gemma":[0.9977585,0.0000465486,0.00008987516,0.00109443,0.00005963677,0.00002449218,0.0002368633,0.00001089241,0.000678778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9169782,"threshold_uncertainty_score":0.3362134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02264597973774949,"score_gpt":0.2727877480307897,"score_spread":0.2501417682930402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}