{"id":"W4383873049","doi":"10.1093/eurheartj/ehad372","title":"Ethnicity, consanguinity, and genetic architecture of hypertrophic cardiomyopathy","year":2023,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council Canada; Science and Technology Development Fund; Department of Health and Aged Care, Australian Government; National Institute for Health and Care Research; British Heart Foundation; Wellcome Trust","keywords":"Medicine; Hypertrophic cardiomyopathy; Consanguinity; Ethnic group; Genetic architecture; Cardiomyopathy; Internal medicine; Cardiology; Genetics; Pediatrics; Environmental health; Heart failure; Population; Anthropology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005946411,0.0001907826,0.000154898,0.00058413,0.0003731384,0.0004239237,0.0001939646,0.0002271163,0.002820028],"category_scores_gemma":[0.001753325,0.00009485997,0.0002348526,0.0004901483,0.0002848586,0.0002383078,0.0003024118,0.0001897091,0.0002138464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001276143,"about_ca_system_score_gemma":0.0001681441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002928324,"about_ca_topic_score_gemma":0.003881269,"domain_scores_codex":[0.9996774,0.0001082029,0.00003548379,0.00008478715,0.00005074028,0.00004330797],"domain_scores_gemma":[0.999299,0.0001725246,0.0002723,0.00007655265,0.00006909132,0.0001103979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000147978,0.00001243301,0.9959033,0.000008931488,0.0000730931,0.0001881381,0.0001188145,0.00003291558,0.0007605221,0.00007504019,0.0000570861,0.002621711],"study_design_scores_gemma":[0.000003082442,0.00003378252,0.9989873,0.000007194613,0.00002709929,0.0004814431,0.00009553305,0.0001114659,0.00006319043,0.00005728483,0.0001307204,0.00000189313],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988423,0.0003844075,0.000112591,0.00003773826,0.000004802386,0.000002850937,0.00006938732,0.000002337551,0.0005436701],"genre_scores_gemma":[0.9997035,0.00008409551,0.00005288679,0.00001218993,0.000004613521,0.000001521434,0.00005388291,0.000001573773,0.00008570672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002928324,"threshold_uncertainty_score":0.009433866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04914223308632844,"score_gpt":0.3024839907217453,"score_spread":0.2533417576354169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}