{"id":"W4383894387","doi":"10.1097/qad.0000000000003654","title":"No evidence of rapid reversibility of tenofovir alafenamide and/or integrase strand transfer inhibitor-associated weight gain","year":2023,"lang":"en","type":"article","venue":"AIDS","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Stichting HIV Monitoring; Ministerie van Volksgezondheid, Welzijn en Sport","keywords":"Discontinuation; Tenofovir alafenamide; Medicine; Weight gain; Weight change; Confidence interval; Cobicistat; Dolutegravir; Internal medicine; Human immunodeficiency virus (HIV); Weight loss; Body weight; Antiretroviral therapy; Viral load; Immunology; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004221295,0.0004108241,0.0007494268,0.0003490355,0.0002011002,0.0009818826,0.0007126307,0.0005818639,0.004402192],"category_scores_gemma":[0.007717114,0.0003250938,0.001919194,0.0005580958,0.0003489685,0.0005979229,0.0005633265,0.001079374,0.0003900136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004467939,"about_ca_system_score_gemma":0.0005330662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007343299,"about_ca_topic_score_gemma":0.005711277,"domain_scores_codex":[0.99801,0.0005993961,0.0001952931,0.0006791238,0.0003161681,0.0002000062],"domain_scores_gemma":[0.9954931,0.001339226,0.002218961,0.0005760045,0.0001996305,0.0001732023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003591468,0.00006233079,0.9754173,0.0002985775,0.002176411,0.0003179796,0.0002006513,0.0005415856,0.001482524,0.0002281171,0.0001750417,0.01550802],"study_design_scores_gemma":[0.00006529719,0.0006048198,0.9957384,0.00006519048,0.0005027147,0.0007356499,0.0001019257,0.0009208682,0.0002482677,0.0001693167,0.0008348149,0.00001272021],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913913,0.00402106,0.001279238,0.0001507798,0.00003247794,0.00003714704,0.001729276,0.00002330374,0.001335494],"genre_scores_gemma":[0.9982362,0.0003309222,0.0002204648,0.00003531958,0.00001268693,0.00001664698,0.0007636738,0.000008810809,0.00037519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007343299,"threshold_uncertainty_score":0.02232456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03695197240868815,"score_gpt":0.3225681788708246,"score_spread":0.2856162064621364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}