{"id":"W4383895041","doi":"10.1021/acs.biochem.3c00260","title":"Cross-Binding of Four Adenosine/ATP Aptamers to Caffeine, Theophylline, and Other Methylxanthines","year":2023,"lang":"en","type":"article","venue":"Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Aptamer; Theophylline; Adenosine; Isothermal titration calorimetry; Caffeine; Chemistry; DNA; Biochemistry; Adenosine triphosphate; RNA; Biophysics; Molecular biology; Biology; Pharmacology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002090655,0.0002003295,0.0002156312,0.00008048534,0.00006938521,0.00002445514,0.0001773486,0.0001985035,0.000004163192],"category_scores_gemma":[0.0002034185,0.0001747013,0.0001075501,0.0003508387,0.0001667923,0.000002803203,0.0001694164,0.00006900993,0.000006499939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008916558,"about_ca_system_score_gemma":0.00002840534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001477354,"about_ca_topic_score_gemma":0.000003133005,"domain_scores_codex":[0.9989048,0.00001731184,0.000244971,0.0004379445,0.0001469185,0.0002481171],"domain_scores_gemma":[0.9992837,0.00002099572,0.0001099121,0.0003781198,0.0001028262,0.0001044116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005001169,0.00001654194,0.00303083,0.00004961856,0.00005798853,0.000003658101,0.0000236743,0.00000465203,0.9939406,0.000006451892,0.001229086,0.001586893],"study_design_scores_gemma":[0.0001661749,0.00007554862,0.0007128171,0.00003580668,0.00002452759,0.00001249534,0.00008566906,0.00003875687,0.9904659,0.00002758733,0.008134896,0.0002198504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985831,0.0001952697,0.000232398,0.0002444786,0.00004422413,0.00009285899,0.0001044475,0.00007771974,0.0004255414],"genre_scores_gemma":[0.9920459,0.0001120314,0.003927664,0.0002129848,0.000204034,0.000009086218,0.00007175256,0.00003240848,0.003384077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00690581,"threshold_uncertainty_score":0.712411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654239231738675,"score_gpt":0.3185658667434241,"score_spread":0.3020234744260373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}