{"id":"W4383895265","doi":"10.1016/s2352-3018(23)00170-4","title":"Lenacapavir: an attractive option, but proceed with caution","year":2023,"lang":"en","type":"letter","venue":"The Lancet HIV","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"AIDS Vancouver; University of British Columbia","funders":"","keywords":"Medicine; Regimen; Capsid; Dosing; Human immunodeficiency virus (HIV); Pharmacology; Internal medicine; Virology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002333951,0.0002564944,0.0003985062,0.00007982802,0.0003469989,0.00003600421,0.0003949246,0.000492577,0.0002156239],"category_scores_gemma":[0.00002754819,0.0001407237,0.00005989652,0.0001270447,0.0002927591,0.00009130281,0.00005231237,0.00180092,0.01141212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009599656,"about_ca_system_score_gemma":0.0001261671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002277882,"about_ca_topic_score_gemma":0.00009037074,"domain_scores_codex":[0.9984229,0.00033201,0.0001399364,0.0003840611,0.00008703894,0.0006340483],"domain_scores_gemma":[0.9990918,0.0001586022,0.0001113735,0.000526497,0.00009397885,0.00001774649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003297103,0.00004919675,0.0003222957,0.00004228359,0.0005380172,0.0001676824,0.000343556,0.000002643631,0.002117468,0.00007945376,0.9953219,0.0006858042],"study_design_scores_gemma":[0.001486263,0.0004207836,0.005436408,0.00007506616,0.0001213123,0.0001586073,0.0001539347,0.000001689949,0.001704337,0.0002317323,0.9899726,0.0002372842],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.05601915,0.001040336,0.00008791737,0.93279,0.0005004817,0.001453359,0.002693456,0.0006221072,0.004793207],"genre_scores_gemma":[0.1587158,0.00146267,0.0002411918,0.3128414,0.01230224,0.002395852,0.06848656,0.0004386617,0.4431156],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.6199486,"threshold_uncertainty_score":0.9893576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05372274806631021,"score_gpt":0.2915391189057656,"score_spread":0.2378163708394554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}