{"id":"W4383897134","doi":"10.1021/acsomega.3c02664","title":"Structural Conformation and Activity of Spider-Derived Inhibitory Cystine Knot Peptide Pn3a Are Modulated by pH","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Health and Medical Research Council; Medical Research Council; Genentech; National Cancer Institute; National Institutes of Health; Scheme for Promotion of Academic and Research Collaboration; University of Toronto; Australian Research Council; Hospital for Sick Children; University of Queensland; Harvard University","keywords":"Conformational isomerism; Chemistry; Nuclear magnetic resonance spectroscopy; Stereochemistry; Peptide; Intramolecular force; Circular dichroism; Biochemistry; Organic chemistry; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007375784,0.0001144733,0.00007603161,0.00009157971,0.00006552097,0.0001156108,0.000115862,0.0001418064,0.0006539237],"category_scores_gemma":[0.00008792021,0.00005731562,0.000120774,0.00009627788,0.0001056603,0.000131443,0.00007526328,0.0002944219,0.0001183233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001145576,"about_ca_system_score_gemma":0.00004971008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003498736,"about_ca_topic_score_gemma":0.000298939,"domain_scores_codex":[0.9999692,0.000003329983,0.000002107312,0.000008753295,0.000008830331,0.000007750597],"domain_scores_gemma":[0.9999458,0.00001242874,0.00001619113,0.000004244658,0.000006450222,0.00001497161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007240457,0.000006364773,0.0001179804,0.000006481529,0.000001458313,0.00001709036,0.00001007244,0.00002507572,0.9992557,0.00001214491,0.000009868497,0.0004652741],"study_design_scores_gemma":[0.000005248465,0.0001021793,0.0136081,0.000002887141,0.000006481706,0.0001334311,0.00002792146,0.001432515,0.9843291,0.00002634998,0.0003214987,0.000004364816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982236,0.000191902,0.0009178721,0.00001896881,0.000003422453,0.000003697764,0.0001404486,0.00002016941,0.0004798226],"genre_scores_gemma":[0.9969974,0.0002418074,0.001372851,0.00002868171,0.000003268591,0.00001183044,0.0003427212,0.00001600726,0.0009854556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006539237,"threshold_uncertainty_score":0.00218761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379683627425879,"score_gpt":0.2392069410431535,"score_spread":0.2254101047688947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}