{"id":"W4383907583","doi":"10.1038/s41380-023-02149-1","title":"Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder","year":2023,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"National Cancer Institute; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Research Nova Scotia; Ministry of Education, India; Virginia Commonwealth University; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Centro de Investigación Biomédica en Red de Salud Mental; National Alliance for Research on Schizophrenia and Depression; Karolinska Institutet; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; University of Adelaide; European Commission; University of Oxford; Deutsche Forschungsgemeinschaft; Centres de Recerca de Catalunya; University of Louisville; Johns Hopkins University; University of New South Wales; U.S. Department of Veterans Affairs; Rush University; Wayne State University; National Institute on Drug Abuse; University of Pennsylvania; Brain and Behavior Research Foundation; Genome Canada","keywords":"Bipolar disorder; Lithium (medication); Internal medicine; Population; Cohort; Medicine; Psychology; Oncology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002351418,0.0001725792,0.000318169,0.000163535,0.00003950257,0.000007694905,0.00003765843,0.00005756865,0.000003585463],"category_scores_gemma":[0.00001191231,0.00009378096,0.00005079271,0.0003806565,0.0000926389,0.00002774065,0.00002759563,0.00007321917,9.191172e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005734695,"about_ca_system_score_gemma":0.00009932306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002216659,"about_ca_topic_score_gemma":0.000399773,"domain_scores_codex":[0.9989216,0.0001383944,0.0002429704,0.0002237068,0.0002931083,0.0001802643],"domain_scores_gemma":[0.9994389,0.00003810013,0.0001513428,0.000261922,0.0000555281,0.00005422163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005919652,0.0006380678,0.9912335,0.00009997407,0.0003816494,0.000003572043,0.0007999979,0.00002454931,0.0002060432,0.00016169,0.000005100952,0.0005262084],"study_design_scores_gemma":[0.01981974,0.002626897,0.9760888,0.0001382872,0.0003290833,0.000002844819,0.0002452112,0.00005353037,0.0004040095,0.0001237533,0.00007605506,0.00009175501],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990171,0.007530843,0.00001274654,0.001406922,0.00003556694,0.0007680184,0.000034742,0.0000176238,0.00002259073],"genre_scores_gemma":[0.99927,0.00028661,0.0001743432,0.00006469777,0.000005812413,0.00005612193,0.0000547264,0.00002429905,0.00006335521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01514466,"threshold_uncertainty_score":0.3824277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005213329719156706,"score_gpt":0.2078900771514818,"score_spread":0.2026767474323251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}