{"id":"W4383907583","doi":"10.1038/s41380-023-02149-1","title":"Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder","year":2023,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"National Cancer Institute; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Research Nova Scotia; Ministry of Education, India; Virginia Commonwealth University; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Centro de Investigación Biomédica en Red de Salud Mental; National Alliance for Research on Schizophrenia and Depression; Karolinska Institutet; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; University of Adelaide; European Commission; University of Oxford; Deutsche Forschungsgemeinschaft; Centres de Recerca de Catalunya; University of Louisville; Johns Hopkins University; University of New South Wales; U.S. Department of Veterans Affairs; Rush University; Wayne State University; National Institute on Drug Abuse; University of Pennsylvania; Brain and Behavior Research Foundation; Genome Canada","keywords":"Bipolar disorder; Lithium (medication); Internal medicine; Population; Cohort; Medicine; Psychology; Oncology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009151294,0.0003645247,0.0003218321,0.0006128825,0.0003575282,0.0004863794,0.0002733485,0.0004012027,0.001716125],"category_scores_gemma":[0.002256729,0.0001347151,0.0006728893,0.0008894153,0.0002777348,0.0002103972,0.0004439178,0.0004881807,0.0001095445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001925217,"about_ca_system_score_gemma":0.0001904498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004987307,"about_ca_topic_score_gemma":0.005257582,"domain_scores_codex":[0.9993384,0.0003216509,0.00005539044,0.0001501452,0.00007526715,0.00005900855],"domain_scores_gemma":[0.9985033,0.0004395145,0.0006317897,0.0001970963,0.000099929,0.0001282928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003363071,0.00002623107,0.996585,0.000007615658,0.0003171474,0.00006383071,0.00003043115,0.0002467155,0.0006374759,0.00004779496,0.00009071075,0.001610697],"study_design_scores_gemma":[0.00001138063,0.00007545445,0.9978026,0.000002758875,0.000109322,0.0001113291,0.00003022025,0.001632211,0.00006812407,0.00008592412,0.00006723242,0.000003553947],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988637,0.0001398431,0.0004260247,0.00005303852,0.000003872867,0.000005397447,0.0003256202,0.00000839011,0.0001740475],"genre_scores_gemma":[0.9994857,0.00002172204,0.0001415774,0.00001137781,0.000003832175,0.000004550847,0.0002586112,0.000001842114,0.0000708013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004987307,"threshold_uncertainty_score":0.009916544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005213329719156706,"score_gpt":0.2078900771514818,"score_spread":0.2026767474323251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}