{"id":"W4383907732","doi":"10.1002/adtp.202300124","title":"A Modular Antibody‐Oligomer T Cell Engager for Applications in Local Therapies","year":2023,"lang":"en","type":"article","venue":"Advanced Therapeutics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; McMaster University","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada","keywords":"Cytotoxicity; Antibody; Cancer research; Antigen; Immunotherapy; Cancer; Cancer immunotherapy; CTL*; Medicine; Chemistry; Pharmacology; In vitro; Immunology; Internal medicine; CD8; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003492237,0.0002055614,0.0003226124,0.0002905988,0.0001196166,0.0000185314,0.0001768858,0.0001249675,0.0001561644],"category_scores_gemma":[0.0000119514,0.0001814775,0.0001459686,0.0009153727,0.0001444096,0.00007882388,0.00003961241,0.000342713,0.00009147992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001037528,"about_ca_system_score_gemma":0.00008593099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008064269,"about_ca_topic_score_gemma":0.000008546437,"domain_scores_codex":[0.9984492,0.00005851097,0.0002750876,0.0003713043,0.0002997939,0.0005461139],"domain_scores_gemma":[0.9987735,0.0003991654,0.00005013337,0.000548974,0.0001324772,0.00009578692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003115411,0.0002390841,0.001373162,0.0001092251,0.00009326466,0.000009273485,0.001100047,0.001125644,0.8357109,0.0006442519,0.00001120893,0.1592724],"study_design_scores_gemma":[0.005153859,0.0004667382,0.007173671,0.00005032076,0.00006789617,0.00000689359,0.002501849,0.01184133,0.134318,0.005666171,0.8323684,0.0003848259],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9038193,0.004622133,0.07998421,0.002477097,0.000202858,0.004965149,0.00006457896,0.0005581843,0.003306553],"genre_scores_gemma":[0.9832652,0.00281404,0.002744381,0.0008031203,0.0001281794,0.0007480026,0.0001564811,0.0001170042,0.00922357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8323572,"threshold_uncertainty_score":0.7400436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04357636839134153,"score_gpt":0.3795854253508251,"score_spread":0.3360090569594836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}