{"id":"W4383907732","doi":"10.1002/adtp.202300124","title":"A Modular Antibody‐Oligomer T Cell Engager for Applications in Local Therapies","year":2023,"lang":"en","type":"article","venue":"Advanced Therapeutics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; McMaster University","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada","keywords":"Cytotoxicity; Antibody; Cancer research; Antigen; Immunotherapy; Cancer; Cancer immunotherapy; CTL*; Medicine; Chemistry; Pharmacology; In vitro; Immunology; Internal medicine; CD8; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009566874,0.0002687412,0.00009593485,0.00008580168,0.00005194221,0.0001620826,0.0001328638,0.0002757267,0.001174728],"category_scores_gemma":[0.0000618714,0.00006922685,0.0001422295,0.0000638865,0.0000971632,0.0001585656,0.0001560864,0.0003007958,0.0003111387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001516411,"about_ca_system_score_gemma":0.00009738749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001347703,"about_ca_topic_score_gemma":0.0001942106,"domain_scores_codex":[0.9999547,0.000007190978,0.000002855555,0.0000116359,0.00001334461,0.00001020771],"domain_scores_gemma":[0.9999609,0.000005505845,0.00001541494,0.000004545093,0.000005248686,0.000008417795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002165179,0.00001730093,0.00005238812,0.00002144927,0.000002104559,0.00002023752,0.000004895967,0.0002585289,0.9976271,0.0001397106,0.00004250193,0.001792116],"study_design_scores_gemma":[0.0000142043,0.0005046851,0.0007131009,0.000003975905,0.0000101896,0.000172556,0.000007307009,0.002573739,0.9928832,0.00005147174,0.003061267,0.000004359853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690521,0.001760404,0.0258896,0.0001175095,0.00003677875,0.00007626556,0.0001074996,0.0002371859,0.002722706],"genre_scores_gemma":[0.9903234,0.0003585114,0.007542242,0.00003970614,0.000005718597,0.00003009642,0.00005699544,0.000008750376,0.001634549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174728,"threshold_uncertainty_score":0.003929853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04357636839134153,"score_gpt":0.3795854253508251,"score_spread":0.3360090569594836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}