{"id":"W4383908941","doi":"10.1787/399d2c34-en","title":"Oxidative DNA damage leading to chromosomal aberrations and mutations","year":2023,"lang":"en","type":"report","venue":"OECD series on adverse outcome pathways","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada; Carleton University","funders":"","keywords":"Adverse Outcome Pathway; DNA damage; Oxidative damage; DNA; Biology; Oxidative phosphorylation; Upstream (networking); Genetics; Computational biology; Oxidative stress; Computer science; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002261763,0.0009121764,0.0006112824,0.003842471,0.000846719,0.002356783,0.0008738138,0.0009193495,0.02296381],"category_scores_gemma":[0.006642101,0.0003087069,0.001245335,0.004423054,0.0007091032,0.001651545,0.003145777,0.001176249,0.007202883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001454004,"about_ca_system_score_gemma":0.003190923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004255775,"about_ca_topic_score_gemma":0.005179519,"domain_scores_codex":[0.9979353,0.0004192102,0.0001266293,0.0002685344,0.001111503,0.0001389064],"domain_scores_gemma":[0.9972513,0.001013336,0.0006059855,0.000273583,0.0006072496,0.0002485885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0008695005,0.0002717664,0.03716295,0.007817882,0.0004788586,0.002020359,0.0004302526,0.01706052,0.01605242,0.132419,0.3089328,0.4764836],"study_design_scores_gemma":[0.0001193088,0.000208436,0.01893285,0.00119093,0.0002427599,0.002920489,0.0003408751,0.01042042,0.03135854,0.1217493,0.8124053,0.0001107419],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.09175009,0.02806489,0.2063298,0.01221034,0.003042187,0.001989639,0.2665693,0.01573164,0.3743121],"genre_scores_gemma":[0.3844784,0.07557036,0.1885191,0.003620744,0.0005834522,0.001469919,0.2119493,0.002048107,0.1317607],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02296381,"threshold_uncertainty_score":0.07682163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1520668030794322,"score_gpt":0.3842012329740379,"score_spread":0.2321344298946056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}